Evidence map›Paper›PMID 39998089›Full record

ArticleToxins2025

Pore-Forming Protein LIN-24 Enhances Starvation Resilience in

Xinqiang Lan, Mengqi Yang, Jiali Wang, Chunping Huang, Andong Wu, Leilei Cui, Yingqi Guo, Lin Zeng, Xiaolong Guo, Yun Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Microorganisms · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinqiang LanMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.
Mengqi YangMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.
Jiali WangMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.
Chunping HuangMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.ORCID 0009-0008-8668-5931
Andong WuMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.
Leilei CuiMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.
Yingqi GuoInstitutional Center for Shared Technologies and Facilities of the Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China.
Lin ZengInstitutional Center for Shared Technologies and Facilities of the Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China.
Xiaolong GuoSchool of Physical Education, Yunnan Normal University, Kunming 650500, China.
Yun ZhangKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650204, China.
Yang XiangMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.ORCID 0000-0003-3016-0323
Qiquan WangMetabolic Control and Aging, Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi Key Laboratory of Human Aging, Nanchang 330031, China.

Funding

Foundation of Nanchang University 28740105National Key R&D Program, Ministry of Science and Technology of China 2023YFC3603300, 2023YFF1001000National Natural Science Foundation of China 82471591, 82460283, 32360136Natural Science Foundation of Jiangxi Province 2024SSY07161 and 20221ZDG020070
6 · The paper itself

Abstract

The ability to survive starvation is a critical evolutionary adaptation, yet the molecular mechanisms underlying this capability remain incompletely understood. Pore-forming proteins (PFPs) are typically associated with immune defense, where they disturb the membranes of target cells. However, the role of PFPs in non-immune functions, particularly in metabolic and structural adaptations to starvation, is less explored. Here, we investigate the aerolysin-like PFP LIN-24 in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsLipid MetabolismMitochondrial DynamicsPore Forming Cytotoxic ProteinsStarvationAnimalsMitochondriaCaenorhabditis elegans ProteinsPore Forming Cytotoxic Proteinsdonut-shaped mitochondriafatty acid degradationLIN-24pore-forming proteinskeletal musclestarvation

Identifiers

PMID39998089
PMCPMC11860826

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.