In one paragraphArticle in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Letícia Oliveira SantosLaboratory of Neurochemistry and Cellular Biology, Health Sciences Institute, Federal University of Bahia, Av. Reitor Miguel Calmon s/n Vale do Canela, Salvador 40231-300, BA, Brazil.
Julita Maria Pereira BorgesLaboratory of Neurochemistry and Cellular Biology, Health Sciences Institute, Federal University of Bahia, Av. Reitor Miguel Calmon s/n Vale do Canela, Salvador 40231-300, BA, Brazil.ORCID 0000-0003-3969-8146 Juliana Lago LeiteDepartment of Organic Chemistry Chemistry Institute, Federal University of Bahia, R. Barão de Jeremoabo, 147-Ondina, Salvador 40170-115, BA, Brazil.
Mauricio Moraes VictorDepartment of Organic Chemistry Chemistry Institute, Federal University of Bahia, R. Barão de Jeremoabo, 147-Ondina, Salvador 40170-115, BA, Brazil.ORCID 0000-0003-1236-1973 Adriana Lopes da SilvaLaboratory of Neurochemistry and Cellular Biology, Health Sciences Institute, Federal University of Bahia, Av. Reitor Miguel Calmon s/n Vale do Canela, Salvador 40231-300, BA, Brazil.
Cleonice Creusa Dos SantosLaboratory of Neurochemistry and Cellular Biology, Health Sciences Institute, Federal University of Bahia, Av. Reitor Miguel Calmon s/n Vale do Canela, Salvador 40231-300, BA, Brazil.
Victor Diógenes Amaral da SilvaLaboratory of Neurochemistry and Cellular Biology, Health Sciences Institute, Federal University of Bahia, Av. Reitor Miguel Calmon s/n Vale do Canela, Salvador 40231-300, BA, Brazil.ORCID 0000-0001-8032-9663 Ravena Pereira do NascimentoLaboratory of Neurochemistry and Cellular Biology, Health Sciences Institute, Federal University of Bahia, Av. Reitor Miguel Calmon s/n Vale do Canela, Salvador 40231-300, BA, Brazil.ORCID 0000-0002-2915-3030 Silvia Lima CostaLaboratory of Neurochemistry and Cellular Biology, Health Sciences Institute, Federal University of Bahia, Av. Reitor Miguel Calmon s/n Vale do Canela, Salvador 40231-300, BA, Brazil.ORCID 0000-0002-8975-3871 Funding
Bahia State Research Foundation (FAPESB) Process Nº 2957/2013, RED0016/2013National Council for Scientific and Technological Development (CNPq) Process Noº 312388/2021-7; CNPq-INCT Excitotoxicity and Neuroprotection
6 · The paper itselfAbstract
Monocrotaline (MCT) has well-characterized hepatotoxic and pneumotoxic effects attributed to its active pyrrole metabolites. Studies have previously shown that astrocytes and neurons are targets of MCT, and that toxicity is attributed to astrocyte P450 metabolism to reactive metabolites. However, little is known about MCT toxicity and metabolism by brain endothelial cells (BECs), cells that, together with astrocytes, are specialized in xenobiotic metabolism and neuroprotection. Therefore, in the present study, we evaluated the toxicity of MCT in BECs, and the effects on astrocyte reactivity and neuronal viability in vitro. MCT was purified from
Indexed as
AstrocytesBrainEndothelial CellsMonocrotalineAnimalsCells, CulturedCell SurvivalCoculture TechniquesCrotalariaNeuronsPyrrolizidine AlkaloidsRatsRats, WistarMonocrotalinePyrrolizidine Alkaloidsastrocytesblood–brain barrierbrain endothelial cellsmonocrotalineneurotoxicity
Identifiers
PMID39998082
PMCPMC11860515
What OpenQuestion holds
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LicenceCC BY
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