Evidence map›Paper›PMID 39998072›Full record

ArticleToxins2025

Single-Chain Variable Fragments: Targeting Snake Venom Phospholipase A

Ying Jia, Ariane Garcia, Elizabeth Reyes

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying JiaSchool of Integrative Biological and Chemical Sciences, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.ORCID 0000-0003-0740-8028
Ariane GarciaSchool of Integrative Biological and Chemical Sciences, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.
Elizabeth ReyesSchool of Integrative Biological and Chemical Sciences, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.

Funding

Identifying the Interactions between Animal Toxins and Human nAChRs: The Role of Snake PLA2 in Interacting with nAChR alpha SubunitsR15NS128563 · NINDS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI JIA, YING · 2022 to 2024
$448k
NIH HHS R15NS128563NINDS NIH HHS R15 NS128563
6 · The paper itself

Abstract

Snakebite is a critical global public health issue, causing substantial mortality and morbidity, particularly in tropical and subtropical regions. The development of innovative antivenoms targeting snake venom toxins is therefore of paramount importance. In this study, we adopted an epitope-directed approach to design three degenerate 15-mer peptides based on amino acid sequence alignments of snake venom phospholipase A

Indexed as

AntiveninsCrotalid VenomsPhospholipases A2Serine ProteasesSingle-Chain AntibodiesAmino Acid SequenceAnimalsFemaleImmunoglobulin GMiceMice, Inbred BALB CAntiveninsCrotalid VenomsImmunoglobulin GPhospholipases A2Serine ProteasesSingle-Chain Antibodiesimmunogenicityimmunoglobulin GpeptidePLA2serine proteasesingle-chain variable fragmentsnakebite

Identifiers

PMID39998072
PMCPMC11860530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.