Evidence map›Paper›PMID 39998057›Full record

ArticleTropical medicine and infectious disease2025

A Case of Persistent KSHV Viremia in the Context of HIV, SARS-CoV-2, and Other Co-Infections.

Humaira Lambarey, Melissa J Blumenthal, Prishanta Chinna, Vincent N Naude, Lauren Jennings, Catherine Orrell, Georgia Schäfer

Abstract readCase Reports
In one paragraph

Article in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Humaira LambareyInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.ORCID 0009-0005-1765-8137
Melissa J BlumenthalInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.ORCID 0000-0002-1865-0795
Prishanta ChinnaInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.
Vincent N NaudeInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.ORCID 0000-0002-0275-1727
Lauren JenningsDesmond Tutu HIV Centre and Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0003-4749-2404
Catherine OrrellInstitute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0003-1134-7475
Georgia SchäferInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.ORCID 0000-0003-1044-3828

Funding

ACSR Young Investigator PilotEuropean and Developing Countries Clinical Trials Partnership EDCTP2 TMA2018SF-2446-KSHV/HIV morbidityICGEB SAWBP/PHD/001Poliomyelitis Research Foundation (PRF) 22/87South African Medical Research Council (SAMRC) SIRSouth African National Research Foundation (NRF) 14208
6 · The paper itself

Abstract

Despite the high prevalence of latent Kaposi's sarcoma-associated herpesvirus (KSHV) infections in patients from endemic areas with a high human immunodeficiency virus (HIV) prevalence, KSHV lytic reactivation in the context of other co-infections is not well understood. Lytic KSHV infections can contribute to severe inflammatory symptoms and KSHV-associated pathogenesis. We have previously reported on KSHV reactivation upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure in a non-hospitalised cohort of people living with HIV (PLWH). From this cohort, we identified a 34-year-old male who presented for routine HIV care in May 2021 with an unusually high KSHV viral load (VL) of 189,946.3 copies/10

Indexed as

COVID-19human immunodeficiency virus (HIV)Kaposi’s sarcoma-associated herpesvirus (KSHV or HHV-8)people living with HIV (PLWH)severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Identifiers

PMID39998057
PMCPMC11860674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.