Toxicity Evaluation of Sulfobetainized Branched Polyethyleneimine via Antibacterial and Biocompatibility Assays.

Mehtap Sahiner, Selin S Suner, Sahin Demirci, Ramesh S Ayyala, Nurettin Sahiner

Abstract read

In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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5 · Who and what money

Authors and funding

5 authors.

Mehtap SahinerDepartment of Bioengineering, Faculty of Engineering, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.ORCID 0000-0001-8666-7954

Selin S SunerDepartment of Chemistry, Faculty of Sciences, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.ORCID 0000-0002-3524-0675

Sahin DemirciDepartment of Food Engineering, Faculty of Engineering, Istanbul Aydin University, Florya Halit Aydin Campus, 34153 Istanbul, Turkey.

Ramesh S AyyalaDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC21, Tampa, FL 33612, USA.

Nurettin SahinerDepartment of Chemistry, Faculty of Sciences, Canakkale Onsekiz Mart University, Terzioglu Campus, 17100 Canakkale, Turkey.ORCID 0000-0003-0120-530X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Branched polyethyleneimine (PEI), possessing different types of amines-e.g., primary, secondary, and tertiary-in the polymer chains are well known for their antibacterial properties and DNA condensing ability, affording substantial advantages in many biomedical uses, including gene therapy. However, because of PEI's toxicity, depending on the molecular weight, its widespread biomedical use is hindered. Therefore, in this study, PEIs with different molecular weights-i.e., 600, 1200, and 1800 g/mol-were modified with 1,3-propane sultone, undergoing a sulfobetainization reaction in a single step to attain a zwitterionic structure: sulfobetainized PEI (b-PEI). The sulfobetainization reaction was carried out twice to increase the zwitterionic repeating unit on PEI chains. The increasing number of SO

Indexed as

betainized PEIbiocompatible polyethyleneiminemultiple betainizationsulfobetainizationzwitter ionic PEI

Identifiers

PMID39997951

DOI10.3390/toxics13020136

PMCPMC11860753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.