Evidence map›Paper›PMID 39997941›Full record

ArticleToxics2025

Interactions Between BMP2/BMP4 Gene Polymorphisms and Fluoride Exposure on Essential Hypertension: A Cross-Sectional Study in China.

Yue Gao, Qingbo Wang, Junhua Wu, Yang Liu, Xin Wang, Yanhui Gao, Yanmei Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue GaoCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China.
Qingbo WangCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China.
Junhua WuCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China.
Yang LiuCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China.
Xin WangCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China.
Yanhui GaoCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China.
Yanmei YangCenter for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin 150081, China.

Funding

National Key R&D Program of China 2022YFC2503000National Natural Science Foundation of China 30972561
6 · The paper itself

Abstract

(1) Objective: To evaluate the relationship between fluoride exposure, interactions of BMP2/BMP4 gene polymorphisms, and fluoride exposure on essential hypertension. (2) Methods: A cross-sectional study was conducted among 725 participants in a high-fluoride region of Shanxi Province, China. Urinary fluoride concentrations were measured as indicators of fluoride exposure. Hypertension was diagnosed based on standard guidelines. BMP2 (rs1005464) and BMP4 (rs17563) polymorphisms were genotyped. Logistic regression and interaction models were performed to evaluate associations and interactions between fluoride exposure, gene polymorphisms, and hypertension. (3) Results: Higher urinary fluoride concentrations were significantly associated with an increased risk of hypertension, exhibiting a dose-dependent relationship. The rs1005464 (G > A) polymorphism of BMP2 was identified as a protective factor against hypertension in individuals with the AG + AA genotype. Significant interactions were observed between the BMP2 rs1005464 and BMP4 rs17563 polymorphisms, influencing hypertension risk. Additionally, both multiplicative and additive interactions between high fluoride exposure and the BMP4 rs17563 polymorphism were identified, highlighting the combined impact of environmental and genetic factors on hypertension. (4) Conclusions: Fluoride exposure is positively associated with hypertension. BMP2 gene polymorphisms affect the risk of hypertension, and BMP4 gene polymorphisms may modify the impact of fluoride on hypertension.

Indexed as

BMP2/4fluoridegene-environment interactionhypertensionsingle nucleotide polymorphism

Identifiers

PMID39997941
PMCPMC11860847

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.