ReviewToxics2025
Uncovering the Potential Link Between Polychlorinated Biphenyls and Cardiovascular Diseases: A Comprehensive Analysis.
Review in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Genetic Polymorphisms as Key Modulators of Cardiovascular Risk from Endocrine-Disrupting Chemicals.Genes · 2026Review
- PCB 118 Exposure Modulates Chromatin Organization, Ribosome Biogenesis, and Autophagy-Related Pathways in Neuron-like: A Transcriptomic Analysis.International journal of molecular sciences · 2026Article
- Mitochondrial dysfunction as a potential pathway linking DL-PCB exposure to intrauterine growth retardation.Environmental health : a global access science source · 2026Article
- Polychlorinated biphenyls and breast cancer: evidence, mechanisms, and risk management.Frontiers in cell and developmental biology · 2026Review
- Association of Persistent Organic Pollutants Polychlorinated Biphenyls and Dioxins with Cardiovascular-Kidney-Metabolic Syndrome and Its Prognosis: A Nationally Representative Study.Cardiorenal medicine · 2026Article
- Exposure to an environmentally relevant mixture of polychlorinated biphenyls affects mitochondrial bioenergetics and plasticity.Redox biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundA family of persistent organic pollutants, known as polychlorinated biphenyls (PCBs), are extensively found in the environment and may be harmful to the cardiovascular system. Systematic reviews and meta-analyses are required to thoroughly evaluate the association between PCB exposure and cardiovascular disease (CVDs), despite the fact that studies on the subject have produced inconsistent results.
objectiveThe purpose of this study was to investigate the relationship between PCBs exposure and cardiovascular disease risk in order to provide more conclusive data to promote public health actions.
methodsThe studies that met the inclusion criteria were screened out using the databases PubMed, Web of Science, ScienceDirect, and Cochrane Library. The comprehensive effect size (OR) was calculated using the random-effects model; the study's heterogeneity was analyzed using I
resultsA meta-analysis of 11 studies revealed that total PCBs (OR = 1.56, 95% CI: 1.20-1.75), non-dioxin-like PCBs (NDL-PCBs) (OR = 1.33, 95% CI: 1.15-1.53), and dioxin-like PCBs (DL-PCBs) (OR = 1.31, 95% CI: 1.10-1.57) were all found to be positively associated with the risk of cardiovascular disease. Subgroup analysis revealed that study type, biomaterials, and literature quality were the most significant drivers of variation. Furthermore, certain PCB homologues, such as non-dioxin-like (NDL)-PCB153 and dioxin-like (DL)-PCB118, are highly related with cardiovascular disease.
conclusionsAccording to this meta-analysis, exposure to PCBs may increase the risk of cardiovascular disease. Notwithstanding major drawbacks, our results emphasize the significance of lowering exposure to PCBs and offering a solid theoretical basis for public health initiatives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.