Evidence map›Paper›PMID 39997833›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Tattoo Ink Metal Nanoparticles: Assessment of Toxicity In Vitro and with a Novel Human Ex Vivo Model.

Beatrice Battistini, Daniela Lulli, Beatrice Bocca, Maria Luigia Carbone, Carmela Ramondino, Stefano Caimi, Alessio Capone, Ezio Maria Nicodemi, Elena Dellambra, Isabella De Angelis and 1 more

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Beatrice BattistiniDepartment of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-5847-2575
Daniela LulliExperimental Immunology Laboratory, IDI-IRCCS, 00167 Rome, Italy.
Beatrice BoccaDepartment of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-6503-6026
Maria Luigia CarboneExperimental Immunology Laboratory, IDI-IRCCS, 00167 Rome, Italy.ORCID 0000-0002-3350-1210
Carmela RamondinoExperimental Immunology Laboratory, IDI-IRCCS, 00167 Rome, Italy.
Stefano CaimiDepartment of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0001-5338-4026
Alessio CaponeMolecular and Cell Biology Laboratory, IDI-IRCCS, 00167 Rome, Italy.
Ezio Maria NicodemiDepartment of Plastic Surgery, IDI-IRCCS, 00167 Rome, Italy.
Elena DellambraMolecular and Cell Biology Laboratory, IDI-IRCCS, 00167 Rome, Italy.ORCID 0000-0002-4329-3312
Isabella De AngelisDepartment of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Cristina Maria FaillaExperimental Immunology Laboratory, IDI-IRCCS, 00167 Rome, Italy.ORCID 0000-0001-5991-8914

Funding

Italian Ministry of Health RC2018-2020Italian Ministry of Health RF-2019-12369805
6 · The paper itself

Abstract

Tattoo inks contain varying amounts of metal nanoparticles (NPs) < 100 nm that, due to their unique physicochemical properties, may have specific biological uptake and cause skin or systemic toxicities. The toxic effects of certified reference standards of metal NPs and samples of commercially available tattoo inks were investigated using an in vitro system and a novel human ex vivo model. In vitro toxicity was evaluated using vitality assays on human skin cells (HaCaT cell line, primary fibroblasts, and keratinocytes). No toxicity was observed for Al

Indexed as

metalnanoparticletattootoxicity

Identifiers

PMID39997833
PMCPMC11858130

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.