ArticleNanomaterials (Basel, Switzerland)2025
Exposure of Polystyrene Nano- and Microplastics in Increasingly Complex In Vitro Intestinal Cell Models.
Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Nanoplastics Impair Neuroimmune Integrity Via Cellular Retention and Multiple Organelle Stress.Journal of hazardous materials advances · 2026Article
- Co-exposure to polystyrene nanoparticles and tetrabromobisphenol A induces genotoxicity and interferes with intestinal barrier differentiation.Cell biology and toxicology · 2026Article
- Tracing theEnvironment & health (Washington, D.C.) · 2026Article
- Microplastics and Nanoplastics in the Human Intestine: A Review of Health Implications and Possible Dietary Interventions.Advances in nutrition (Bethesda, Md.) · 2026Review
- Enzyme-Loaded Microcapsules as Intracellular Organelles for the Degradation of Nanoplastics by Cells.ACS nano · 2026Article
- Polystyrene Nanoplastics Increase Macrophage Bactericidal Activity Through a Mechanism Involving Reactive Oxygen Species and Itaconate.Nanomaterials (Basel, Switzerland) · 2026Article
- Artificial Intelligence-Driven Food Safety: Decoding Gut Microbiota-Mediated Health Effects of Non-Microbial Contaminants.Foods (Basel, Switzerland) · 2025Review
- Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies.Particle and fibre toxicology · 2025Article
- Article
- Health impacts of microplastic and nanoplastic exposure.Nature medicine · 2025Review
- Following the fate of polystyrene micro and nanobeads duringCurrent research in food science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the rise in global plastic production and the presence of plastic waste in the environment, microplastics are considered an emerging environmental contaminant. Human exposure and the impact of microplastics on human health are not well studied. Recent studies have observed the presence of microplastics in human tissues and several studies have noted toxicity in in vitro and in vivo mammalian models. We examined the impact of polystyrene nano- and microplastics in increasingly complex intestinal cell models. Using an undifferentiated Caco-2 mono-culture model, we assessed particle association, cytotoxicity, and particle clearance/retention, whereas in differentiated mono- and tri-culture transwell models, we assessed membrane integrity and particle translocation. Only 50 nm and 500 nm particles were internalized in the undifferentiated cells; however, no signs of cellular toxicity were observed at any concentrations tested. Additionally, polystyrene particles had no impact on barrier integrity, but the 50 nm particles were able to cross to the basolateral side, albeit attenuated in the tri-culture model that had a mucus layer. This study reduced some of the variability common to MNPL testing across various in vitro models, but further testing is needed to fully understand the potential effects of human MNPL exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.