Evidence map›Paper›PMID 39997464›Full record

ReviewInfectious disease reports2025

Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.

Julien A Clain, Morgane Picard, Henintsoa Rabezanahary, Sonia André, Steven Boutrais, Ella Goma Matsetse, Juliette Dewatines, Quentin Dueymes, Elise Thiboutot, Gina Racine and 5 more

Abstract readReview
In one paragraph

Review in Infectious disease reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Julien A ClainCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-7231-0847
Morgane PicardInstitut national de la santé et de la recherche médicale (INSERM) U1124, Université Paris Cité, 75006 Paris, France.
Henintsoa RabezanaharyCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Sonia AndréInstitut national de la santé et de la recherche médicale (INSERM) U1124, Université Paris Cité, 75006 Paris, France.
Steven BoutraisCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0009-0008-2871-8395
Ella Goma MatsetseCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Juliette DewatinesCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Quentin DueymesCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Elise ThiboutotCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Gina RacineCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Calaiselvy SoundaramourtyInstitut national de la santé et de la recherche médicale (INSERM) U1124, Université Paris Cité, 75006 Paris, France.
Fabrizio MammanoInstitut national de la santé et de la recherche médicale (INSERM) U1124, Université Paris Cité, 75006 Paris, France.ORCID 0000-0002-9193-7696
Pierre CorbeauInstitut de Génétique Humaine, CNRS-Université de Montpellier UMR9002, 34094 Montpellier, France.ORCID 0000-0002-8576-6683
Ouafa Zghidi-AbouzidCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Jérôme EstaquierCentre Hospitalier Universitaire (CHU) de Québec Centre de Recherche, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-9432-8044

Funding

CIHR HBF-123682, PJT-175182, HBF-126786, and MOP-133476
6 · The paper itself

Abstract

BACKGROUND/

objectivesOver the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection.

methodsBy using non-human primate models of pathogenic and non-pathogenic lentiviral infections, we aimed at identifying the cells and tissues in which the virus persists, despite antiretroviral therapy (ART). Indeed, the eradication of viral reservoirs is a major challenge for HIV cure.

resultsWe present a series of results performed in rhesus macaques of Chinese origin deciphering the virological and immunological events associated with ART that can be of interest for people living with HIV.

conclusionsThis model could be of interest for understanding in whole body the clinical alteration that persist despite ART.

Indexed as

aidsapoptosisB cellCD4curemacaquemonocytereservoirSIVTfh

Identifiers

PMID39997464
PMCPMC11855486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.