Evidence map›Paper›PMID 39997446›Full record

ArticleJournal of fungi (Basel, Switzerland)2025

Candidemia in ICU Patients: What Are the Real Game-Changers for Survival?

Bianca Leal de Almeida, Caroline Agnelli, Thaís Guimarães, Teresa Sukiennik, Paulo Roberto Passos Lima, Mauro José Costa Salles, Giovanni Luís Breda, Flavio Queiroz-Telles, Ana Verena Almeida Mendes, Luís Fernando Aranha Camargo and 10 more

Abstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  2. Pathogens (Basel, Switzerland) · 2026
    Observational
  3. Emergence and Comparative Analysis ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Overview of Risk Factors and Diagnosis of Invasive Candidiasis.Journal of fungi (Basel, Switzerland) · 2026
    Review
  7. Article
  8. Review
  9. Changing Climate, ChangingJournal of fungi (Basel, Switzerland) · 2025
    Review
  10. Early-Onset Candidemia in Adult Intensive Care Units.Diagnostics (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Is candidemia mortality inevitable or a consequence of inadequate guideline adherence?The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Bianca Leal de AlmeidaInstituto do Câncer do Estado de São Paulo, School of Medicine, Hospital Infection Control and Infectious Diseases Service, University of São Paulo, São Paulo 01246-000, Brazil.
Caroline AgnelliDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04024-002, Brazil.
Thaís GuimarãesHospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil.ORCID 0000-0002-7282-5453
Teresa SukiennikSanta Casa de Misericórdia de Porto Alegre, Porto Alegre 90050-170, Brazil.
Paulo Roberto Passos LimaDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04024-002, Brazil.
Mauro José Costa SallesDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04024-002, Brazil.ORCID 0000-0002-5443-6024
Giovanni Luís BredaDepartamento de Saúde Coletiva, Universidade Federal do Paraná, Curitiba 81531-990, Brazil.
Flavio Queiroz-TellesDepartamento de Saúde Coletiva, Universidade Federal do Paraná, Curitiba 81531-990, Brazil.ORCID 0000-0001-7034-2418
Ana Verena Almeida MendesHospital São Rafael, Salvador 41253-190, Brazil.
Luís Fernando Aranha CamargoDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04024-002, Brazil.
Hugo Manuel Paz MoralesHospital Erasto Gaertner, Curitiba 81520-060, Brazil.
Viviane Maria de Carvalho Hessel DiasHospital Nossa Senhora das Graças, Curitiba 80810-040, Brazil.
Afonso Rafael da Silva JuniorLaboratório de Microbiologia da Divisão de Laboratório Central, Pathology Department, Hospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil.ORCID 0009-0008-9509-9248
João Nóbrega de Almeida JuniorDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04024-002, Brazil.ORCID 0000-0002-3766-026X
Camila de Melo PiconeHospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil.ORCID 0000-0002-2455-5831
Evangelina da Motta Pacheco Alves de AraújoLaboratório de Microbiologia da Divisão de Laboratório Central, Pathology Department, Hospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil.ORCID 0009-0006-3836-3431
Edson AbdalaInstituto do Câncer do Estado de São Paulo, School of Medicine, Hospital Infection Control and Infectious Diseases Service, University of São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0003-0765-6654
Flávia RossiLaboratório de Microbiologia da Divisão de Laboratório Central, Pathology Department, Hospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil.
Arnaldo Lopes ColomboDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04024-002, Brazil.ORCID 0000-0003-0793-8491
Marcello Mihailenko Chaves MagriHospital das Clínicas da Faculdade de Medicina USP (FMUSP), São Paulo 05403-010, Brazil.ORCID 0000-0001-7996-8265

Funding

CAPES Foundation PDSE 88881.187981/2018-01FUNDAÇÃO DE AMPARO A PESQUISA DO ESTADO DE SÃO PAULO, BRAZIL 2021/10599-3
6 · The paper itself

Abstract

Candidemia infection remains a critical challenge in intensive care units (ICUs), with high morbidity and mortality rates despite advances in therapeutic practices. This multicenter prospective surveillance study assessed the epidemiology, clinical management, and mortality predictors of candidemia in critically ill patients across two periods (2010-2012 and 2017-2018) in 11 tertiary hospitals in Brazil. Among 314 ICU patients with candidemia, the overall mortality rate was 60.2%, with no significant reduction over time (58.8% vs. 62.6%,

Indexed as

cancercandidemiacatheter removalechinocandinsintensive care unit

Identifiers

PMID39997446
PMCPMC11855959

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.