Evidence map›Paper›PMID 39997385›Full record

ReviewJournal of fungi (Basel, Switzerland)2025

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics.

Vinicius Alves, Daniel Zamith-Miranda, Susana Frases, Joshua D Nosanchuk

Abstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Pharmacological advances inJournal of enzyme inhibition and medicinal chemistry · 2026
    Review
  2. Review
  3. Article
  4. Enhancement of Polysaccharides inJournal of fungi (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Caspofungin Reshapes the Extracellular Vesicles Metabolome ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. A Pilot Metabolomic Study for DiagnosingInternational journal of molecular sciences · 2025
    Article
  15. Review
  16. Article
  17. Evaluation of the Effects ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vinicius AlvesLaboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0002-8541-3183
Daniel Zamith-MirandaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-7532-2432
Susana FrasesLaboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0001-5875-9886
Joshua D NosanchukDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-9905-5754

Funding

The biology of Cryptococcus neoformans melanizationR01AI171093 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall, JOSHUA D NOSANCHUK · 2023 to 2026
$3.2M
Development and optimization of a nitric oxide releasing microparticle-basedtopical treatment for onychomycosisR41AI165204 · NIAID · ZYLO THERAPEUTICS, INC. · PI DRAGANSKI, ANDREW R, NOSANCHUK, JOSHUA D · 2022 to 2023
$600k
Candida auris extracellular vesicles subvert host immune responsesR21AI156104 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI NOSANCHUK, JOSHUA D · 2021 to 2022
$462k
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 0NIAID NIH HHS R01 AI171093NIAID NIH HHS R21 AI156104NIAID NIH HHS R41 AI165204
6 · The paper itself

Abstract

Metabolomics has emerged as a transformative tool in the study of microbes, including pathogenic fungi, facilitating the identification of unique metabolic profiles that elucidate their pathogenic mechanisms, host interactions, and treatment resistance. This review highlights key applications of metabolomics in understanding fungal metabolites essential for human virulence, such as mycotoxins produced by various fungal species, including

Indexed as

fungal infectionmetabolomicssecondary metabolism

Identifiers

PMID39997385
PMCPMC11856446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.