ArticleMarine drugs2025
Isolation, Structure Elucidation and Biological Evaluation of Lomaiviticins F-H, Dimeric Benzofluorene Glycosides from Marine-Derived
Fan Zhang, Wenhui Wang, Doug R Braun, Gene E Ananiev, Weiting Liao, Mary Kay Harper, Scott R Rajski, Tim S Bugni
Abstract read
In one paragraphArticle in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Fan ZhangDepartment of Pulmonary and Critical Care Medicine, Zhongnan Hospital of Wuhan University, TaiKang Center for Life and Medical Sciences, School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-9732-1123 Wenhui WangDepartment of Pulmonary and Critical Care Medicine, Zhongnan Hospital of Wuhan University, TaiKang Center for Life and Medical Sciences, School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan 430071, China.
Doug R BraunPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.
Gene E AnanievSmall Molecule Screening & Synthesis Facility, UW Carbone Cancer Center, Madison, WI 53705, USA.
Weiting LiaoDepartment of Pulmonary and Critical Care Medicine, Zhongnan Hospital of Wuhan University, TaiKang Center for Life and Medical Sciences, School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan 430071, China.
Mary Kay HarperDepartment of Medicinal Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA.
Scott R RajskiPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-0238-8411 Tim S BugniPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-4502-3084 Funding
Novel antimicrobials targeting MDR pathogens from animal microbial symbiontsU19AI142720 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R · 2019 to 2023
$30.1MMetabolomics driven discovery of drug leads from symbiotic bacteriaU19AI109673 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, CURRIE, CAMERON ROBERT · 2014 to 2018
$16.2MTR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2012 to 2019
$9.4MNMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4MUltra High Resolution Mass Spectrometer for Biomedical ResearchS10OD018475 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI GE, YING · 2015 to 2015
$2.0MOmics approaches for natural products discoveryR01GM104192 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUGNI, TIMOTHY S · 2013 to 2019
$2.0MNational Natural Science Foundation of China, National Key Research and Development Program of China, 82273826, 2022YFC2804300NIAID NIH HHS U19 AI109673NIAID NIH HHS U19 AI142720NIGMS NIH HHS P41 GM103399NIGMS NIH HHS R01 GM104192NIGMS NIH HHS R24 GM141526NIH HHS S10 OD018475NIH HHS U19 AI109673 and U19 AI142720, R01 GM104192
6 · The paper itselfAbstract
The discovery of new natural products remains a cornerstone of therapeutic innovation, and effective analytical tools for rapid dereplication can significantly accelerate this process. Using Isotopic Fine Structure (IFS) mass spectrometry, we rapidly identified three new dimeric benzofluorene glycosides, lomaiviticins F-H (
Indexed as
Antineoplastic AgentsBiological ProductsFluorenesGlycosidesMicromonosporaAquatic OrganismsCell Line, TumorHumansMagnetic Resonance SpectroscopyMolecular StructureAntineoplastic AgentsBiological ProductsFluorenesGlycosidesbenzofluoreneisotopic fine structurelomaiviticinMicromonospora sp.
Identifiers
PMID39997189
PMCPMC11857394
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