Evidence map›Paper›PMID 39997123›Full record

ArticleBiomimetics (Basel, Switzerland)2025

Bone Fillers with Balance Between Biocompatibility and Antimicrobial Properties.

Bogdan Valeriu Sorca, Durmuş Alpaslan Kaya, Madalina Georgiana Albu Kaya, Marius Enachescu, Daniela-Madalina Ghetu, Laura-Bianca Enache, Iulian Boerasu, Alina Elena Coman, Laura Cristina Rusu, Rodica Constantinescu and 1 more

Abstract read
In one paragraph

Article in Biomimetics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bogdan Valeriu SorcaDepartment of Oral Pathology, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.
Durmuş Alpaslan KayaDepartment of Field Crops, Faculty of Agriculture, Hatay Mustafa Kemal University, Antakya-Hatay 31034, Turkey.ORCID 0000-0003-3544-9214
Madalina Georgiana Albu KayaCollagen Department, INCDTP-Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania.ORCID 0000-0001-9960-2244
Marius EnachescuCenter for Surface Science and Nanotechnology, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.ORCID 0000-0002-8451-8231
Daniela-Madalina GhetuInstitute of Cellular Biology and Pathology "Nicolae Simionescu", 8 B. P. Hasdeu Street, District 5, 050568 Bucharest, Romania.
Laura-Bianca EnacheCenter for Surface Science and Nanotechnology, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.ORCID 0000-0003-0991-0003
Iulian BoerasuCenter for Surface Science and Nanotechnology, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.
Alina Elena ComanCollagen Department, INCDTP-Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania.ORCID 0000-0003-1062-3650
Laura Cristina RusuDepartment of Oral Pathology, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.ORCID 0000-0001-6375-4705
Rodica ConstantinescuCollagen Department, INCDTP-Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania.
Irina TitorencuInstitute of Cellular Biology and Pathology "Nicolae Simionescu", 8 B. P. Hasdeu Street, District 5, 050568 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Millions of people request bone regeneration every year, and the market for bone grafting materials has a positive trend. The most used biomaterials applied to replace and regenerate bone are based on collagen and different types of ceramics in order to mimic natural bone matrix. However, there are a lot of implant-associated infections after surgery, or the implants are rejected because of reduced biocompatibility, and this is why the research into graft bone materials is still a challenge. This study aims to develop and characterize novel biomimetic bone fillers which have simultaneously both antimicrobial properties and biocompatibility with human bone marrow-derived mesenchymal stem cells (BMSCs). Type I collagen and calcium triphosphate in a ratio of 1:1 were used as a control, according to our previous studies, and ZnO, functionalized with different percentages of

Indexed as

antimicrobial activitybiocompatibilitybone fillerscollagenessential oil

Identifiers

PMID39997123
PMCPMC11852756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.