Evidence map›Paper›PMID 39997050›Full record

ArticleDiseases (Basel, Switzerland)2025

Impact of HPV Types and Dendritic Cells on Recurrent Respiratory Papillomatosis' Aggressiveness.

Ellen Eduarda Fernandes, Maria Leticia de Almeida Lança, Yan Aparecido de Souza, Vivian Narana El-Achkar, Victor Costa, Román Carlos, Alfredo Ribeiro-Silva, Laura Sichero, Luisa Lina Villa, Jorge Esquiche León and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chemopreventive Potential of Artemisinin andInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ellen Eduarda FernandesDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos 12245-000, Brazil.ORCID 0000-0003-2088-7756
Maria Leticia de Almeida LançaDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos 12245-000, Brazil.
Yan Aparecido de SouzaDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos 12245-000, Brazil.ORCID 0000-0001-5996-6246
Vivian Narana El-AchkarDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos 12245-000, Brazil.
Victor CostaDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos 12245-000, Brazil.
Román CarlosCentro Clínico de Cabeza y Cuello, Guatemala City 01010, Guatemala.
Alfredo Ribeiro-SilvaDepartment of Pathology and Forensic Medicine, Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto 14049-900, Brazil.
Laura SicheroCenter for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-903, Brazil.ORCID 0000-0002-7999-5818
Luisa Lina VillaCenter for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-903, Brazil.
Jorge Esquiche LeónOral Pathology, Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-904, Brazil.ORCID 0000-0002-9668-5870
Estela KaminagakuraDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University-UNESP, São José dos Campos 12245-000, Brazil.ORCID 0000-0003-2456-4516

Funding

Fapesp 16/24019-0
6 · The paper itself

Abstract

objectiveThis study assesses the associations between dendritic cells, HPV 6 and 11, and Recurrent Respiratory Papillomatosis (RRP) aggressiveness.

methodsThe Derkay score was calculated using information obtained from the medical records. Biopsies from 36 patients with juvenile RRP (JRRP) and 43 adult RRP (ARRP) patients were analyzed under light microscopy, and their clinical data were collected. Immunohistochemical analysis using antibodies against CD83, CD1a, Factor XIIIa, and S100 was performed, and inflammatory cells were quantified. Data obtained were analyzed using the chi-squared test, in addition to the Mann-Whitney and Z tests for two proportions, considering a confidence interval of 95% and

resultsA higher quantity of S100 was identified in the epithelium (

conclusionsAn increased quantity of dendritic cells is present in individuals diagnosed with RRP, regardless of age, and this may be related to the lower Derkay index, regardless of the HPV type detected.

Indexed as

dendritic cellshuman papillomavirus virusinflammatory cellsjuvenile laryngeal papillomatosislaryngeal papillomatosis

Identifiers

PMID39997050
PMCPMC11854725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.