Evidence map›Paper›PMID 39997037›Full record

ArticleDiseases (Basel, Switzerland)2025

Comparative Analysis of Blood MMP-9 Concentration in Alcohol- and Opioid-Addicted Patients.

Tamar Kartvelishvili, Nelly Sapojnikova, Nino Asatiani, Lali Asanishvili, Victor Sokhadze, Nestan Sichinava, Zaza Chikovani

Abstract read
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In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tamar KartvelishviliAndronikashvili Institute of Physics, I. Javakhishvili Tbilisi State University, Tbilisi 0162, Georgia.
Nelly SapojnikovaAndronikashvili Institute of Physics, I. Javakhishvili Tbilisi State University, Tbilisi 0162, Georgia.
Nino AsatianiAndronikashvili Institute of Physics, I. Javakhishvili Tbilisi State University, Tbilisi 0162, Georgia.
Lali AsanishviliAndronikashvili Institute of Physics, I. Javakhishvili Tbilisi State University, Tbilisi 0162, Georgia.
Victor SokhadzeAndronikashvili Institute of Physics, I. Javakhishvili Tbilisi State University, Tbilisi 0162, Georgia.
Nestan SichinavaNarcological Clinic "Nishati", Tbilisi 0186, Georgia.
Zaza ChikovaniNarcological Clinic "Nishati", Tbilisi 0186, Georgia.

Funding

SHOTA RUSTAVELI NATIONAL SCIENCE FOUNDATION OF GEORGIA STEM-22-320
6 · The paper itself

Abstract

BACKGROUND/

objectivesIn brain physiology and disease, MMP-9 is a significant and apparently peculiar factor. Numerous studies have implicated neuroinflammatory processes involving MMP-9 in the pathophysiology of addiction. This study aims to evaluate plasma MMP-9 level as a biomarker for the stages of alcohol and opioid addiction.

methodsThe case subjects were patients with opioid and alcohol addiction. The quantitative assessment of MMP-9 plasma concentration was performed using monoclonal antibodies against human MMP-9.

resultsMMP-9 levels in the plasma of patients with alcohol and opioid dependence differ from MMP-9 concentrations in apparently healthy donors. During the intoxication stage, MMP-9 concentrations in individuals with alcohol and opioid dependence are similar and higher than in the control group. While the MMP-9 level is close to the control level after alcohol withdrawal, it stays increased during opioid withdrawal. When MMP-9 levels in plasma were measured in three distinct intoxicated states (light, moderate, and heavy) in cases of alcohol addiction, the results were all similar. Two distinct opioid intoxicated states (methadone and buprenorphine) and three withdrawals-following methadone, buprenorphine, and heroin abuse-were associated with high MMP-9 levels.

Indexed as

alcohol addictionMMP-9opioid addictionplasma

Identifiers

PMID39997037
PMCPMC11853769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.