Evidence map›Paper›PMID 39997016›Full record

ArticleBiosensors2025

A Ratiometric Fluorescence Nano pH Biosensor for Live-Cell Imaging Using Cerasome.

Zhongqiao Zhang, Xiaoshan Luo, Xuanbo Wang, Meng Liu, Xiuli Yue, Zhaozhu Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhongqiao ZhangSchool of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Xiaoshan LuoNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China.
Xuanbo WangNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China.
Meng LiuCyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Suzhou Medical College, Soochow University, Suzhou 215123, China.
Xiuli YueSchool of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150001, China.
Zhaozhu ZhengNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China.ORCID 0000-0001-7035-9252

Funding

Natural Science Foundation of Jiangsu Province BK2019021597
6 · The paper itself

Abstract

The development of a robust and biocompatible pH-sensing platform is critical for monitoring intracellular processes and diagnosing diseases. Here, we present a smart ultrastable ratiometric fluorescence nano pH sensor based on silica-coated liposome nanoparticles (cerasome, 138.4 nm). The sensor integrates pH-sensitive dye, pyranine, within cerasome, achieving enhanced photostability, sensitivity, and biocompatibility. Its unique ratiometric design enables precise pH monitoring with minimal photobleaching and quenching, covering a linear detection range of pH 6.25-8.5. The hybrid nanoparticles exhibit high morphological stability, making them suitable for real-time intracellular pH measurement. This novel platform shows great promise for applications in cellular biology, disease diagnosis, and therapeutic monitoring, offering a versatile tool for biomedical research.

Indexed as

Biosensing TechniquesNanoparticlesArylsulfonatesFluorescenceFluorescent DyesHumansHydrogen-Ion ConcentrationLiposomesSilicon DioxideArylsulfonatesFluorescent DyesLiposomespyranineSilicon Dioxidecerasomelive cellsnanoparticlespH sensorratiometric fluorescence

Identifiers

PMID39997016
PMCPMC11852597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.