Evidence map›Paper›PMID 39996977›Full record

ArticleBiosensors2025

Artificial-Intelligence Bio-Inspired Peptide for Salivary Detection of SARS-CoV-2 in Electrochemical Biosensor Integrated with Machine Learning Algorithms.

Marcelo Augusto Garcia-Junior, Bruno Silva Andrade, Ana Paula Lima, Iara Pereira Soares, Ana Flávia Oliveira Notário, Sttephany Silva Bernardino, Marco Fidel Guevara-Vega, Ghabriel Honório-Silva, Rodrigo Alejandro Abarza Munoz, Ana Carolina Gomes Jardim and 5 more

Abstract read
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marcelo Augusto Garcia-JuniorDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.ORCID 0000-0002-9724-6503
Bruno Silva AndradeDepartment of Biological Sciences, Laboratory of Bioinformatics and Computational Chemistry, State University of Southwest of Bahia (UESB), Jequié 45205-490, Brazil.ORCID 0000-0002-8031-9454
Ana Paula LimaDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.
Iara Pereira SoaresPost-Graduation Program in Genetics and Biochemistry, Laboratory of Nanobiotechnology-Dr Luiz Ricardo Goulart, Federal University of Uberlândia (UFU), Uberlândia 38408-100, Brazil.
Ana Flávia Oliveira NotárioPost-Graduation Program in Genetics and Biochemistry, Laboratory of Nanobiotechnology-Dr Luiz Ricardo Goulart, Federal University of Uberlândia (UFU), Uberlândia 38408-100, Brazil.
Sttephany Silva BernardinoDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.
Marco Fidel Guevara-VegaDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.
Ghabriel Honório-SilvaDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.
Rodrigo Alejandro Abarza MunozInstitute of Chemistry, Federal University of Uberlândia (UFU), Uberlândia 38408-100, Brazil.ORCID 0000-0001-8230-5825
Ana Carolina Gomes JardimInstitute of Biosciences, Languages, and Exact Sciences (Ibilce), São Paulo State University (Unesp), São José do Rio Preto 15054-000, Brazil.ORCID 0000-0002-6348-7923
Mário Machado MartinsDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.ORCID 0000-0001-7381-2788
Luiz Ricardo GoulartDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.ORCID 0000-0002-1803-4861
Thulio Marquez CunhaDepartment of Pulmonology, School of Medicine, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.
Murillo Guimarães CarneiroFaculty of Computing, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.ORCID 0000-0002-2915-8990
Robinson Sabino-SilvaDepartment of Physiology, Laboratory of Nanobiotechnology-Dr. Luiz Ricardo Goulart, Innovation Center in Salivary Diagnostic and Nanobiotechnology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlândia 38408-100, Brazil.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior #23038.014934/2020-59Coordenação de Aperfeicoamento de Pessoal de Nível Superior #458143/2014Fundação de Amparo à Pesquisa do Estado de Minas Gerais #APQ-00476-20Fundação de Amparo à Pesquisa do Estado de Minas Gerais #APQ-02148-21Fundação de Amparo à Pesquisa do Estado de Minas Gerais #APQ-02872-16Fundação de Amparo à Pesquisa do Estado de Minas Gerais #APQ-03613-17National Council for Scientific and Technological Development #406840/2022-9National Council for Scientific and Technological Development #465669/2014-0
6 · The paper itself

Abstract

Developing affordable, rapid, and accurate biosensors is essential for SARS-CoV-2 surveillance and early detection. We created a bio-inspired peptide, using the SAGAPEP AI platform, for COVID-19 salivary diagnostics via a portable electrochemical device coupled to Machine Learning algorithms. SAGAPEP enabled molecular docking simulations against the SARS-CoV-2 Spike protein's RBD, leading to the synthesis of Bio-Inspired Artificial Intelligence Peptide 1 (BIAI1). Molecular docking was used to confirm interactions between BIAI1 and SARS-CoV-2, and BIAI1 was functionalized on rhodamine-modified electrodes. Cyclic voltammetry (CV) using a [Fe(CN)

Indexed as

Biosensing TechniquesCOVID-19Machine LearningPeptidesSalivaSARS-CoV-2AlgorithmsArtificial IntelligenceElectrochemical TechniquesHumansMolecular Docking SimulationSpike Glycoprotein, CoronavirusPeptidesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2artificial intelligencebio-inspired peptidesbiosensorsCOVID-19electrochemical detectionsalivary diagnostics

Identifiers

PMID39996977
PMCPMC11853606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.