Evidence map›Paper›PMID 39996969›Full record

ArticleBiosensors2025

Focal Molography Allows for Affinity and Concentration Measurements of Proteins in Complex Matrices with High Accuracy.

Lorin Dirscherl, Laura S Merz, Ronya Kobras, Peter Spies, Andreas Frutiger, Volker Gatterdam, Dominik M Meinel

Abstract read
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lorin DirscherlInstitute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, FHNW, Hofackerstrasse 30, 4132 Muttenz, Basel-Landschaft, Switzerland.ORCID 0009-0006-3099-6365
Laura S MerzInstitute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, FHNW, Hofackerstrasse 30, 4132 Muttenz, Basel-Landschaft, Switzerland.ORCID 0009-0005-8452-178X
Ronya KobrasInstitute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, FHNW, Hofackerstrasse 30, 4132 Muttenz, Basel-Landschaft, Switzerland.ORCID 0009-0002-7284-3085
Peter SpiesInstitute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, FHNW, Hofackerstrasse 30, 4132 Muttenz, Basel-Landschaft, Switzerland.
Andreas FrutigerLino Biotech AG, Soodstrasse 52, 8134 Adliswil, Zurich, Switzerland.ORCID 0000-0002-2523-8918
Volker GatterdamLino Biotech AG, Soodstrasse 52, 8134 Adliswil, Zurich, Switzerland.ORCID 0000-0001-7078-9885
Dominik M MeinelInstitute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, FHNW, Hofackerstrasse 30, 4132 Muttenz, Basel-Landschaft, Switzerland.ORCID 0000-0003-2328-9794

Funding

Innosuisse - Swiss Innovation Agency 61708.1 IP-LS
6 · The paper itself

Abstract

Characterizing biomolecular receptor-ligand interactions is critical for research and development. However, performing analyses in complex, biologically relevant matrices, such as serum, remains challenging due to non-specific binding that often impairs measurements. Here, we evaluated Focal Molography (FM) for determining

Indexed as

Biosensing TechniquesProteinsAnimalsCattleHumansKineticsProtein BindingProteinsantibody–antigen interactionbio-layer interferometrybiomolecular affinitycomplex matricesfocal molographykinetic affinity measurementnon-specific bindingquantification of biomarkersreceptor–ligand interactionsurface plasmon resonance

Identifiers

PMID39996969
PMCPMC11853488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.