Evidence map›Paper›PMID 39996908›Full record

ReviewCurrent oncology (Toronto, Ont.)2025

Evidence-Based Recommendations on the Use of Immunotherapies and Monoclonal Antibodies in the Treatment of Male Reproductive Cancers.

Farhan Khalid, Zubair Hassan Bodla, Sai Rakshith Gaddameedi, Raymart Macasaet, Karan Yagnik, Zahra Niaz, Peter N Fish, Doantrang Du, Shazia Shah

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Farhan KhalidDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
Zubair Hassan BodlaDepartment of Internal medicine, Graduate Medical Education, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.ORCID 0000-0003-1203-2766
Sai Rakshith GaddameediDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
Raymart MacasaetDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
Karan YagnikDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.ORCID 0000-0001-9345-6071
Zahra NiazDepartment of Medicine, Al-Aleem Medical College, Lahore 54000, Pakistan.
Peter N FishDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
Doantrang DuDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
Shazia ShahDepartment of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of male reproductive cancers, including prostate, testicular, and penile cancers, has risen in recent years, raising important health concerns. Prostate cancer is the second leading cause of cancer-related mortality in men, while penile cancer, though rare, typically affects men over 60. Testicular cancer, with a lifetime risk of about 0.4% in men, is most common among adolescents and young adults, decreasing sharply after the age of 40. Traditional treatments include chemotherapy, radiation, surgery, and combinations thereof, but advancements in immunotherapy and monoclonal antibodies are showing promising results, particularly for genitourinary cancers. These therapies, targeting immune checkpoints and tumor-specific antigens, are gaining traction as effective alternatives for resistant cases. This review provides evidence-based recommendations on current and emerging immunotherapy and monoclonal antibody treatments for male reproductive cancers, highlighting future directions to optimize patient outcomes.

Indexed as

Antibodies, MonoclonalGenital Neoplasms, MaleImmunotherapyEvidence-Based MedicineHumansMaleAntibodies, Monoclonalgenitourinary carcinomasimmunotherapymale reproductive tract cancersmonoclonal antibodiesprostate cancertreatment modalities

Identifiers

PMID39996908
PMCPMC11854063

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.