Evidence map›Paper›PMID 39996857›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Clinical Utility of Liquid Biopsy for the Early Diagnosis of EGFR-Mutant Advanced Lung Cancer Patients in a Real-Life Setting (CLEAR Study).

Ramy Samaha, Rola El Sayed, Raafat Alameddine, Marie Florescu, Mustapha Tehfe, Bertrand Routy, Arielle Elkrief, Wiam Belkaid, Antoine Desilets, Xiaoduan Weng and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ramy SamahaHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Rola El SayedHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Raafat AlameddineHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.ORCID 0000-0002-0516-8705
Marie FlorescuHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Mustapha TehfeHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.ORCID 0000-0002-1380-5110
Bertrand RoutyHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Arielle ElkriefHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Wiam BelkaidHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Antoine DesiletsHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.ORCID 0000-0002-9382-7597
Xiaoduan WengHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Rami NassabeinHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.
Félix Blanc-DurandHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.ORCID 0000-0002-5277-1515
Gurvinder KenthOncology, AstraZeneca Canada, Inc., Mississauga, ON L4Y 1M4, Canada.
Goulnar KasymjanovaThe Anne and Peter Brojde Lung Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.ORCID 0000-0003-3182-7628
Jason AgulnikPulmonary and Medical Oncology, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Normand BlaisHematology/Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 3E4, Canada.ORCID 0000-0003-2698-4362

Funding

AstraZeneca (Canada) Study Code D5162R00013
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAdultAgedAged, 80 and overCirculating Tumor DNAEarly Detection of CancerErbB ReceptorsFemaleHumansLiquid BiopsyMaleMiddle AgedMutationProspective StudiesCirculating Tumor DNAEGFR protein, humanErbB Receptorscirculating tumor DNA (ctDNA)liquid biopsy (LBx)lung cancermolecular diagnosticsnext-generation sequencing (NGS)non-small cell lung cancer (NSCLC)personalized medicine

Identifiers

PMID39996857
PMCPMC11854366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.