Evidence map›Paper›PMID 39996852›Full record

ArticleCurrent issues in molecular biology2025

Levels of Proangiogenic Molecules and Terminal Complement Complex C5b-9 in the Crown of Circulating sEVs in Patients with Recurrent Glioblastomas: Relationship with Tumor Molecular Characteristics.

Natalia Yunusova, Eldar Tulendinov, Dmitry Svarovsky, Anastasia Ryabova, Irina Kondakova, Anastasia Ponomaryova, Sergey Vtorushin, Stanislav Tabakaev, Dmitry Korshunov, Tatiana Shtam and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Natalia YunusovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.ORCID 0000-0003-4595-4177
Eldar TulendinovDepartment of Biochemistry and Molecular Biology with the Course of Clinical Laboratory Diagnostics, Siberian State Medical University (Siberian State Medical University of the Ministry of Health of the Russian Federation), Moskovsky Tract, 2, 634050 Tomsk, Russia.
Dmitry SvarovskyCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.ORCID 0000-0002-8985-009X
Anastasia RyabovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.ORCID 0000-0002-7171-8728
Irina KondakovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.ORCID 0000-0002-0947-8778
Anastasia PonomaryovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.
Sergey VtorushinCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.ORCID 0000-0002-1195-4008
Stanislav TabakaevCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.ORCID 0000-0002-1427-0162
Dmitry KorshunovCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.
Tatiana ShtamSt. Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre "Kurchatov Institute", Orlova Roshcha 1, 188300 Gatchina, Russia.ORCID 0000-0003-0651-4785
Svetlana TamkovichDepartment of Clinical Biochemistry, Novosibirsk State University, 2, Pirogov St., 630090 Novosibirsk, Russia.ORCID 0000-0001-7774-943X
Evgeny ChoynzonovCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str., 5, 634009 Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating small extracellular vesicles (sEVs) are emerging as potential biomarkers for glioblastoma progression. This study aimed to compare the levels of matrix metalloproteinases (MMP2 and MMP9), terminal complement complex (C5b-9), and VEGF-A in circulating sEVs in glioblastoma patients (GBMPs) with and without tumor recurrence. Using differential ultracentrifugation, sEVs were isolated from blood samples of GBMPs with no tumor recurrence for over one year (n = 6) and after first relapse (n = 14). The vesicles were characterized and quantified using flow cytometry. In both groups, C5b-9 was predominantly detected on tumor-specific circulating sEVs (glial fibrillary acidic protein (GFAP)-positive sEVs) with high VEGF-A expression, while C5b-9 was significantly less frequent on sEVs with low VEGF-A expression (

Indexed as

extracellular vesiclesGFAPglioblastoma recurrencematrix metalloproteinasesMGMT gene promoter methylationp53terminal complement complexVEGF-A

Identifiers

PMID39996852
PMCPMC11854864

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.