Evidence map›Paper›PMID 39996786›Full record

ArticleCells2025

A Critical Role of Intracellular PD-L1 in Promoting Ovarian Cancer Progression.

Rui Huang, Brad Nakamura, Rosemary Senguttuvan, Yi-Jia Li, Antons Martincuks, Rania Bakkar, Mihae Song, David K Ann, Lorna Rodriguez-Rodriguez, Hua Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Epigenetic regulation in gynecological cancers: a paradigm shift in immunotherapy strategies.Journal of experimental & clinical cancer research : CR · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rui HuangDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0002-4103-8537
Brad NakamuraDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Rosemary SenguttuvanDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0003-4856-4051
Yi-Jia LiDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Antons MartincuksDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-8127-3833
Rania BakkarDepartment of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Mihae SongDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-6457-6023
David K AnnDepartment of Diabetes Complication and Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Lorna Rodriguez-RodriguezDepartment of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.
Hua YuDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

Funding

City of Hope Markel-Friedman Accelerator Fund City of Hope Markel-Friedman Accelerator Fund
6 · The paper itself

Abstract

Disrupting the interaction between tumor-cell surface PD-L1 and T cell membrane PD-1 can elicit durable clinical responses. However, only about 10% of ovarian cancer patients respond to PD-1/PD-L1 blockade. Here, we show that PD-L1 expression in ovarian cancer-patient tumors is predominantly intracellular. Notably, PARP inhibitor treatment highly increased intracellular PD-L1 accumulation in both ovarian cancer-patient tumor samples and cell lines. We investigated whether intracellular PD-L1 might play a critical role in ovarian cancer progression. Mutating the PD-L1 acetylation site in PEO1 and ID8

Indexed as

B7-H1 AntigenDisease ProgressionIntracellular SpaceOvarian NeoplasmsAcetylationAnimalsApoptosisCell Line, TumorCell ProliferationDNA DamageFemaleHumansMiceB7-H1 AntigenCD274 protein, humanintracellular PD-L1ovarian cancerprogression

Identifiers

PMID39996786
PMCPMC11853747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.