Evidence map›Paper›PMID 39996763›Full record

ArticleCells2025

Differential Regulation of Nav1.1 and SCN1A Disease Mutant Sodium Current Properties by Fibroblast Growth Factor Homologous Factors.

Ashley Frazee, Agnes Zybura, Theodore R Cummins

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashley FrazeeBiology Department, School of Science, Indiana University Indianapolis, Indianapolis, IN 46202, USA.
Agnes ZyburaBiology Department, School of Science, Indiana University Indianapolis, Indianapolis, IN 46202, USA.
Theodore R CumminsBiology Department, School of Science, Indiana University Indianapolis, Indianapolis, IN 46202, USA.

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1M
Sodium channels and electrogenesis in sensory neuronsR01NS053422 · NINDS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CUMMINS, THEODORE R · 2006 to 2019
$4.6M
Role of dimer formation in modulating neuronal sodium channel propertiesR21NS128595 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI CUMMINS, THEODORE R · 2023 to 2023
$428k
NIH HHS 1R01NS053422-04A1NIH HHS U54NS108874NINDS NIH HHS R01 NS053422NINDS NIH HHS R21 NS128595NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

Fibroblast growth factor homologous factors (FHFs) regulate the activity of several different voltage-gated sodium channels (Na

Indexed as

Fibroblast Growth FactorsMutationNAV1.1 Voltage-Gated Sodium ChannelSodiumAnimalsHEK293 CellsHumansFibroblast Growth FactorsNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, humanSodiumchannelopathyFHF2Ainactivationmigrainevoltage-gated sodium channel

Identifiers

PMID39996763
PMCPMC11853998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.