ArticleCells2025
Metabolomics Profiling Reveals Critical Roles of Indoxyl Sulfate in the Regulation of Innate Monocytes in COVID-19.
Liqing He, Yunke Wang, Fang Yuan, Samantha Morrissey, Anne E Geller, Xiaoling Hu, Raobo Xu, Xipeng Ma, Huang-Ge Zhang, Kenneth McLeish and 3 more
Abstract read
In one paragraphArticle in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Yunke WangImmuno-Oncology Program, Brown Cancer Center, Division of Immunotherapy, MD Department of Surgery, University of Louisville, Louisville, KY 40292, USA.
Fang YuanDepartment of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Samantha MorrisseyDepartment of Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA.
Anne E GellerDepartment of Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA.
Xiaoling HuImmuno-Oncology Program, Brown Cancer Center, Division of Immunotherapy, MD Department of Surgery, University of Louisville, Louisville, KY 40292, USA.
Xipeng MaDepartment of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Huang-Ge ZhangDepartment of Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA.
Kenneth McLeishDivision of Nephrology and Hypertension, Department of Medicine, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0002-7816-3286 Jiapeng HuangDepartment of Anesthesiology and Perioperative Medicine, University of Louisville Hospital, Louisville, KY 40292, USA.ORCID 0000-0002-4794-8400 Jun YanImmuno-Oncology Program, Brown Cancer Center, Division of Immunotherapy, MD Department of Surgery, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0003-2922-422X Funding
Low Density Neutrophils Link Inflammation and Coagulopathy in COVID-19R01HL158779 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HUANG, JIAPENG, URIARTE, SILVIA M · 2022 to 2025
$2.9MNeutrophil Heterogeneity and Immunopathogenesis of COVID-19 ARDSR01AI172873 · NIAID · UNIVERSITY OF LOUISVILLE · PI Jiapeng Huang, Silvia M Uriarte · 2023 to 2026
$2.3MNHLBI NIH HHS R01 HL158779NIAID NIH HHS R01 AI172873NIH HHS AI128818 and HL158779
6 · The paper itselfAbstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is intricately related to the reprogramming of host metabolism. However, existing studies have mainly focused on peripheral blood samples and barely identified specific metabolites that are critically involved in the pathology of coronavirus disease 2019 (COVID-19). In the current small-scale study, we performed metabolic profiling in plasma (
Indexed as
COVID-19Immunity, InnateIndicanMetabolomicsMonocytesAdultAgedApoptosisBronchoalveolar Lavage FluidFemaleHumansMaleMetabolomeMiddle AgedSARS-CoV-2Tumor Necrosis Factor-alphaIndicanTumor Necrosis Factor-alphaCOVID-19immune regulationindoxyl sulfatemetabolismmonocytes
Identifiers
PMID39996729
PMCPMC11853107
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