Evidence map›Paper›PMID 39996725›Full record

ArticleCells2025

Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors.

Oleksandr Zabiegalov, Adeline Berger, Dhryata Kamdar, Kabirou Adamou, Chuanxi Tian, Martial Mbefo, Mathieu Quinodoz, Florian Udry, Carlo Rivolta, Corinne Kostic and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Oleksandr ZabiegalovUnit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.ORCID 0000-0003-3378-7084
Adeline BergerUnit of Epigenetics of Ocular Diseases, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.ORCID 0000-0003-2986-4489
Dhryata KamdarOphthalmic Genetics Group, Institute of Molecular and Clinical Ophthalmology, 4031 Basel, Switzerland.ORCID 0000-0002-5594-9913
Kabirou AdamouGroup for Retinal Disorders Research, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.
Chuanxi TianUnit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.
Martial MbefoUnit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.
Mathieu QuinodozOphthalmic Genetics Group, Institute of Molecular and Clinical Ophthalmology, 4031 Basel, Switzerland.
Florian UdryUnit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.ORCID 0000-0001-6644-5414
Carlo RivoltaOphthalmic Genetics Group, Institute of Molecular and Clinical Ophthalmology, 4031 Basel, Switzerland.ORCID 0000-0002-0733-9950
Corinne KosticGroup for Retinal Disorders Research, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.ORCID 0000-0003-1006-9733
Yvan ArsenijevicUnit of Retinal Degeneration and Regeneration, Department of Ophthalmology, University of Lausanne, 1004 Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines to allow in vitro studies on retinal progenitors and photoreceptors and their developmental dynamics or properties and to test therapeutic approaches. The isolation of pure progenitor populations or photoreceptor precursors may serve for drug, gene, and cell therapy development. Here, we generated a dual-reporter mouse embryonic stem cell line

Indexed as

Genes, ReporterMouse Embryonic Stem CellsPhotoreceptor CellsRetinaAnimalsCell DifferentiationCell LineCell ProliferationHumansMiceOrganoidscell tracingRax genereporter lineretinal organoidsretinal progenitor cellsstem cells

Identifiers

PMID39996725
PMCPMC11854395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.