Evidence map›Paper›PMID 39996719›Full record

ArticleCells2025

BCL-B Promotes Lung Cancer Invasiveness by Direct Inhibition of BOK.

Palaniappan Ramesh, Amal R Al Kadi, Gaurav M Borse, Maximilian Webendörfer, Gregor Zaun, Martin Metzenmacher, Fabian Doerr, Servet Bölükbas, Balazs Hegedüs, Smiths S Lueong and 6 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Palaniappan RameshDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0009-0002-0823-0364
Amal R Al KadiDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0009-0008-4794-7548
Gaurav M BorseDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
Maximilian WebendörferDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0009-0006-1498-3134
Gregor ZaunDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0002-3813-6961
Martin MetzenmacherDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.
Fabian DoerrMedical Faculty, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0002-0878-0406
Servet BölükbasMedical Faculty, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0001-8275-5957
Balazs HegedüsMedical Faculty, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0002-4341-4153
Smiths S LueongGerman Cancer Consortium (DKTK), Partner Site University Hospital Essen, 45147 Essen, Germany.
Joelle MagneDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Beiyun LiuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Greisly NunezDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Martin SchulerDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0002-2166-3394
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-7332-1417
Halime KalkavanDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0002-0090-4080

Funding

MECHANISMS OF REGULATED CELL DEATHR35CA231620 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2018 to 2026
$9.2M
Advanced Clinician Scientist Programm UMEA² (Medical Faculty, University Duisburg-Essen), the Federal Ministry of Education and Research 01EO2104 (BMBF) 01EO2104German Cancer Aid (Max-Eder Junior Research Group Program, DKH 70115382) DKH 70115382German Research Foundation (DFG, KA 4830/1-1) KA 4830/1-1NCI NIH HHS R35 CA231620
6 · The paper itself

Abstract

Expression of

Indexed as

Lung NeoplasmsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2AnimalsApoptosisCell Line, TumorEpithelial-Mesenchymal TransitionHumansMitochondrial MembranesNeoplasm InvasivenessProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2BCL-2 familyBCL-BBOKcancerdrug-resistanceDTPEMTinvasivenessmitochondrial permeabilizationpersister phenotype

Identifiers

PMID39996719
PMCPMC11853756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.