Evidence map›Paper›PMID 39996711›Full record

ReviewCells2025

Treatment Response in Individual Organs Affected by Chronic Graft-Versus-Host Disease.

Takanobu Morishita, Paul J Martin, Yoshihiro Inamoto

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Advances in treatment of chronic graft-versus-host disease.International journal of hematology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Takanobu MorishitaDepartment of Blood and Marrow Transplantation & Cellular Therapy, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.ORCID 0000-0002-0841-270X
Paul J MartinDivision of Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Yoshihiro InamotoDepartment of Blood and Marrow Transplantation & Cellular Therapy, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.ORCID 0000-0003-4881-0427

Funding

Japan Society for the Promotion of Science 22K08517
6 · The paper itself

Abstract

Chronic graft-versus-host disease (GVHD) occurs in 30-70% of patients after allogeneic hematopoietic cell transplantation (HCT) and increases the risks of morbidity and mortality. Systemic corticosteroids are the standard initial treatment, but one-third of patients require subsequent treatment with other systemic agents. Treatment decisions are often based on physicians' experience. The expected treatment response rates in specific organs affected by chronic GVHD may inform such decisions. In this review, we identify 20 studies reporting treatment response rates in individual organs according to objective criteria, summarize the results, discuss the caveats in data interpretation, identify the unmet needs, and suggest future directions in the field. For cutaneous sclerosis, we observed large discrepancies in organ response rates according to the current NIH criteria and patient-reported improvement, highlighting the need for better measurement tools. High response rates for lung involvement with certain novel drugs deserve further investigation.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationChronic DiseaseHumansTreatment Outcomeaxatilimabbelumosudilchronic graft-versus-host diseaseextracorporeal photopheresisibrutinibkeyword allogeneic hematopoietic cell transplantationorgan responseruxolitinib

Identifiers

PMID39996711
PMCPMC11854124

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.