Evidence map›Paper›PMID 39996639›Full record

ReviewGels (Basel, Switzerland)2025

Hydrogels from Protein-Polymer Conjugates: A Pathway to Next-Generation Biomaterials.

Oubadah Alayoubi, Yağmur Poyraz, Gana Hassan, Sümeyye Berfin Gül, Nergiz Çalhan, Naz Mina Mert Şahin, Megha Gautam, Aylin Kutlu, Bengü Özuğur Uysal, Ebru Demet Akten and 1 more

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Oubadah AlayoubiMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.
Yağmur PoyrazComputational Sciences and Engineering, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.ORCID 0000-0002-5318-7978
Gana HassanMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.ORCID 0009-0005-5133-4865
Sümeyye Berfin GülMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.
Nergiz ÇalhanMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.
Naz Mina Mert ŞahinComputational Sciences and Engineering, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.ORCID 0000-0002-8858-4500
Megha GautamComputational Sciences and Engineering, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.
Aylin KutluMaterials Science and Nanotechnology, School of Graduate Studies, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.
Bengü Özuğur UysalDepartment of Basic Sciences, Faculty of Engineering and Architecture, Altınbaş University, Bağcılar, Istanbul 34218, Türkiye.ORCID 0000-0001-8756-9045
Ebru Demet AktenFaculty of Engineering and Natural Sciences, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.
Önder PekcanFaculty of Engineering and Natural Sciences, Kadir Has University, Cibali, Fatih, Istanbul 34083, Türkiye.ORCID 0000-0002-0082-8209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hybrid hydrogels from protein-polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein-polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These properties allow these conjugates to be used as biocompatible components in biomedical applications. Protein-polymer conjugation is a vital bioengineering strategy in many fields, such as drug delivery, tissue engineering, and cancer therapy. Protein-polymer conjugations aim to create materials with new and unique properties by combining the properties of different molecular components. There are various ways of creating protein-polymer conjugates. PEGylation is one of the most common conjugation techniques where a protein is conjugated with Polyethylene Glycol. However, some limitations of PEGylation (like polydispersity and low biodegradability) have prompted researchers to devise novel synthesis techniques like PEGylation, where synthetic polypeptides are used as the polymer component. This review will illustrate the properties of protein-polymer conjugates, their synthesis methods, and their various biomedical applications.

Indexed as

hybrid hydrogelsPEGylationprotein–polymer conjugates

Identifiers

PMID39996639
PMCPMC11854714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.