ArticleEnvironmental science & technology2025
Quantitative Evaluation of Regulatory Indicators for Brominated Haloacetic Acids in Drinking Water.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Enhanced Formation of Brominated and Nitrogenous Disinfection Byproducts in Drinking Water Disinfection with Chlorocyanurates.Environmental science & technology · 2026Article
- Risks of Birth Defects Following In Utero Exposures to Unregulated Brominated Haloacetic Acids.Birth defects research · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drinking water regulations often use indicators to represent risk associated with broader contaminant groups. To evaluate the efficacy of indicators, a quantitative approach is needed that aligns with the regulatory framework, in which a benchmark value represents an unacceptably high level of a contaminant or contaminant class. This policy microsimulation study develops such an approach in the context of potential regulatory revisions to address brominated HAAs, a class of disinfection byproducts. Likely scenarios include a limit on the sum of nine brominated and chlorinated HAAs (HAA9), on bromide, or on the sum of six brominated HAAs (HAA6Br). The probability of each potential regulatory indicator co-occurring with a high level of HAA6Br was quantified using logistic models. The HAA9 and bromide indicators both performed poorly, with no better than a ∼1 in 4 chance of identifying equivalently high levels of HAA6Br. Furthermore, high false positive rates (>75%) would implicate a substantial number of water systems that do not have high HAA6Br levels. This study reveals the trade-off implicit in the use of regulatory indicators, in which precision (fewer false positives) must be sacrificed to achieve greater coverage (more true positives). The methodology and findings have broad implications for evaluating indicator classes in drinking water policy and research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.