Evidence map›Paper›PMID 39996451›Full record

ArticleJournal of the American Heart Association2025

Sex Differences in the Relationship of Socioeconomic Position With Cardiovascular Disease, Cardiovascular Risk Factors, and Estimated Cardiovascular Disease Risk: Results of the German National Cohort.

Ilais Moreno Velásquez, Sanne A E Peters, Nico Dragano, Karin Halina Greiser, Marcus Dörr, Beate Fischer, Klaus Berger, Anke Hannemann, Renate B Schnabel, Matthias Nauck and 30 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  6. Review
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  8. Journal of the American Heart Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Ilais Moreno VelásquezMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC) Molecular Epidemiology Research Group Berlin Germany.ORCID 0000-0001-6058-8983
Sanne A E PetersThe George Institute for Global Health, School of Public Health Imperial College London UK.ORCID 0000-0003-0346-5412
Nico DraganoInstitute of Medical Sociology, Centre for Health and Society, Medical Faculty and University Hospital Heinrich Heine University Düsseldorf Germany.ORCID 0000-0002-0378-0757
Karin Halina GreiserGerman Cancer Research Center in the Helmholtz Association DKFZ Heidelberg Germany.ORCID 0000-0003-3213-8285
Marcus DörrDepartment of Internal Medicine University Medicine Greifswald Germany.ORCID 0000-0001-7471-475X
Beate FischerDepartment of Epidemiology and Preventive Medicine University of Regensburg Germany.ORCID 0000-0002-3011-6886
Klaus BergerInstitute of Epidemiology and Social Medicine University of Münster Germany.ORCID 0000-0001-8966-3684
Anke HannemannGerman Center of Cardiovascular Research (DZHK) Partner Site Greifswald Germany.ORCID 0000-0003-4420-5449
Renate B SchnabelDepartment of Cardiology, University Heart & Vascular Center Hamburg University Medical Center Hamburg-Eppendorf Hamburg Germany.ORCID 0000-0001-7170-9509
Matthias NauckGerman Center of Cardiovascular Research (DZHK) Partner Site Greifswald Germany.ORCID 0000-0002-6678-7964
Susanne GöttlicherInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health Neuherberg Germany.
Susanne RospleszczInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health Neuherberg Germany.ORCID 0000-0002-4788-2341
Stefan N WillichInstitute of Social Medicine, Epidemiology and Health Economics Charité - Universitätsmedizin Berlin Germany.ORCID 0009-0006-1270-2597
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics Charité - Universitätsmedizin Berlin Germany.ORCID 0000-0002-6089-5163
Matthias B SchulzeDepartment of Molecular Epidemiology German Institute of Human Nutrition Potsdam Rehbruecke Nuthetal Germany.ORCID 0000-0002-0830-5277
Kathrin GüntherLeibniz Institute for Prevention Research and Epidemiology-BIPS Bremen Germany.ORCID 0000-0003-3801-4769
Tilman BrandLeibniz Institute for Prevention Research and Epidemiology-BIPS Bremen Germany.ORCID 0000-0001-5140-7511
Tamara SchikowskiDepartment of Epidemiology IUF-Leibniz Research Institute for Environmental Medicine Düsseldorf Germany.ORCID 0000-0002-4559-9374
Carina EmmelInstitute for Medical Informatics, Biometry and Epidemiology Essen University Hospital Essen Germany.
Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology Essen University Hospital Essen Germany.
Karin B MichelsInstitute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center University of Freiburg Germany.
Rafael MikolajczykInstitute for Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Center for Health Sciences Medical Faculty of the Martin-Luther University Halle-Wittenberg Halle Germany.ORCID 0000-0003-1271-7204
Alexander KluttigInstitute for Medical Epidemiology, Biometrics, and Informatics, Interdisciplinary Center for Health Sciences Medical Faculty of the Martin-Luther University Halle-Wittenberg Halle Germany.
Volker HarthInstitute for Occupational and Maritime Medicine Hamburg (ZfAM) University Medical Centre Hamburg-Eppendorf (UKE) Hamburg Germany.
Nadia ObiInstitute for Occupational and Maritime Medicine Hamburg (ZfAM) University Medical Centre Hamburg-Eppendorf (UKE) Hamburg Germany.ORCID 0000-0002-0903-9142
Stefanie CastellDepartment for Epidemiology Helmholtz Centre for Infection Research Braunschweig Germany.ORCID 0000-0003-1762-8462
Carolina J Klett-TammenDepartment for Epidemiology Helmholtz Centre for Infection Research Braunschweig Germany.ORCID 0000-0001-9685-5369
Wolfgang LiebInstitute of Epidemiology University of Kiel Germany.ORCID 0000-0003-2544-4460
Heiko BecherInstitute of Global Health University Hospital Heidelberg Germany.ORCID 0000-0002-8808-6667
Volker WinklerInstitute of Global Health University Hospital Heidelberg Germany.ORCID 0000-0002-9974-1145
Heike MinnerupInstitute of Epidemiology and Social Medicine University of Münster Germany.ORCID 0000-0002-9706-7599
André KarchInstitute of Epidemiology and Social Medicine University of Münster Germany.ORCID 0000-0003-3014-8543
Claudia Meinke-FranzeInstitute for Community Medicine University Medicine Greifswald Germany.ORCID 0000-0001-6137-9702
Michael LeitzmannDepartment of Epidemiology and Preventive Medicine University of Regensburg Germany.ORCID 0000-0002-0371-2789
Michael J SteinDepartment of Epidemiology and Preventive Medicine University of Regensburg Germany.ORCID 0000-0002-1120-1751
Barbara BohnNAKO e.V. Heidelberg Germany.ORCID 0000-0001-8363-943X
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg Germany.ORCID 0000-0002-1217-4521
Kira TraresDivision of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg Germany.ORCID 0000-0002-1775-3231
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health Neuherberg Germany.ORCID 0000-0001-6645-0985
Tobias PischonMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC) Molecular Epidemiology Research Group Berlin Germany.ORCID 0000-0003-1568-767X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUsing data from the largest German cohort study, we aimed to investigate sex differences in the relationship of socioeconomic position (SEP) with cardiovascular disease (CVD), CVD risk factors, and estimated CVD risk. METHODS AND

resultsA total of 204 780 (50.5% women) participants from the baseline examination of the population-based NAKO (German National Cohort) were included. Logistic, multinomial, and linear regression models were used to estimate sex-specific odds ratios (ORs) and β coefficients with 95% CIs of CVD, CVD risk factors, and very high-risk score (Systemic Coronary Risk Estimation-2) for CVD associated with SEP. Women-to-men ratios of ORs (RORs) with 95% CIs were estimated. In women compared with men, low versus high SEP (educational attainment and relative income) was more strongly associated with myocardial infarction, hypertension, obesity, overweight, elevated blood pressure, antihypertensive medication, and current alcohol consumption, but less strongly with current and former smoking. In women with the lowest versus highest educational level, the OR for a very high 10-year CVD risk was 3.61 (95% CI, 2.88-4.53) compared with 1.72 (95% CI, 1.51-1.96) in men. The women-to-men ROR was 2.33 (95% CI, 1.78-3.05). For the comparison of low versus high relative income, the odds of having a very high 10-year CVD risk was 2.55 (95% CI, 2.04-3.18) in women and 2.25 (95% CI, 2.08-2.42) in men (women-to-men ROR, 1.31 [95% CI, 1.05-1.63]).

conclusionsIn women and men, there was an inverse relationship between indicators of SEP and the likelihood of having several CVD risk factors and a very high 10-year CVD risk. This association was stronger in women, suggesting that CVD risk is more strongly influenced by SEP in women compared with men.

Indexed as

Cardiovascular DiseasesSocial ClassAdultAgedEducational StatusFemaleGermanyHeart Disease Risk FactorsHumansMaleMiddle AgedRisk AssessmentRisk FactorsSex FactorsSocioeconomic Factorscardiovascular diseasecardiovascular riskeducational attainmentincomesocioeconomic position

Identifiers

PMID39996451
PMCPMC12132702

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