Evidence map›Paper›PMID 39996325›Full record

Trial reportStroke2025

Acute Intermittent Hypoxia in People Living With Chronic Stroke: A Case Series.

Gregory E P Pearcey, Alexander J Barry, Milap S Sandhu, Timothy J Carroll, Elliot J Roth, W Zev Rymer

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04019522 (An Exploration of Acute Intermittent Hypoxia as a Tool to Enhance Neural Recovery in Stroke Survivors; a Pilot Safety Study.), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04019522 nacompletednot on this map

An Exploration of Acute Intermittent Hypoxia as a Tool to Enhance Neural Recovery in Stroke Survivors; a Pilot Safety Study.

TypeinterventionalSponsorShirley Ryan AbilityLabRan2019 to 2025Enrolled16ConditionsStrokeArmsAcute Intermittent Hypoxia (AIH)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Phrenic long-term facilitation following acute intermittent hypercapnic-hypoxia in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
    Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gregory E P PearceySchool of Human Kinetics and Recreation, Memorial University of Newfoundland, St. John's, Canada (G.E.P.P.).ORCID 0000-0002-6751-4351
Alexander J BarryShirley Ryan AbilityLab, Chicago, IL (A.J.B., M.S.S., E.J.R., W.Z.R.).ORCID 0000-0002-0904-155X
Milap S SandhuShirley Ryan AbilityLab, Chicago, IL (A.J.B., M.S.S., E.J.R., W.Z.R.).
Timothy J CarrollDepartment of Radiology, University of Chicago, IL (T.J.C.).ORCID 0000-0003-2113-6284
Elliot J RothShirley Ryan AbilityLab, Chicago, IL (A.J.B., M.S.S., E.J.R., W.Z.R.).ORCID 0000-0002-7308-4079
W Zev RymerShirley Ryan AbilityLab, Chicago, IL (A.J.B., M.S.S., E.J.R., W.Z.R.).ORCID 0000-0002-1672-4236

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute intermittent hypoxia (AIH) is a novel therapeutic intervention that facilitates recovery of function, but the tolerability and effectiveness have not been tested in people living with chronic stroke. The purpose here was to examine whether AIH is tolerable and effective in this population.

methodsTen participants with a unilateral, hemispheric stroke were assessed before and after 4 sessions of AIH separated by ≥48 hours in a case series at Shirley Ryan AbilityLab (Chicago). Physician-assessed signs and symptoms (assessed via: repeated symptom reviews, National Institutes of Health Stroke Scale, cranial nerve assessment, a muscle strength test, the Brunnstrom scale, sensory changes, reflexes, assessment of heart and lung status, Fugl-Meyer test, Chedoke-McMaster Stroke Assessment, Modified Ashworth Scale for Spasticity, and Delis Kaplan Executive Function System Color-Word Interference Test) and bilateral upper limb strength (grip and elbow flexion) were assessed before, ≈15 to 30 minutes, and ≈60 minutes after the intervention.

resultsAIH was well-tolerated and there were no adverse events observed. After AIH, grip strength (12.91% and 16.53% improvement at 30 and 60 minutes post-AIH, respectively) and elbow flexion force (5.87% and 7.01% improvement at 30 and 60 minutes post-AIH, respectively) improved in the more-affected limb.

conclusionsAIH is potentially safe and effective for improving strength in the more-affected limb in people living with hemiparetic stroke. Future work should explore the use of AIH to enhance task-specific training-induced plasticity. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04019522.

Indexed as

HypoxiaStrokeStroke RehabilitationAgedAged, 80 and overChronic DiseaseFemaleHand StrengthHumansMaleMiddle AgedRecovery of Functionmuscle strengthrecovery of functionrehabilitationstroketherapy

Identifiers

PMID39996325
PMCPMC11932439

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.