Evidence map›Paper›PMID 39996196›Full record

ArticleCureus2025

Progressive Motor and Cognitive Dysfunction in Fahr's Disease: A Clinical Case Report.

Mrooj M Almutairi, Zahraa J Ahmed, Masooma Y Ahmed, Shalan M Alshalan, Anas E Ahmed

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [A case report of severe hypocalcemia secondary to Fahr's syndrome].Anales del sistema sanitario de Navarra · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mrooj M AlmutairiCollege of Medicine, King Abdulaziz University, Jeddah, SAU.
Zahraa J AhmedCollege of Medicine, Southeast University, Nanjing, CHN.
Masooma Y AhmedCollege of Medicine, Wenzhou Medical University, Wenzhou, CHN.
Shalan M AlshalanEmergency Medicine, King Khalid Hospital, Tabuk, SAU.
Anas E AhmedCollege of Medicine, Jazan University, Jazan, SAU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fahr's disease, or idiopathic basal ganglia calcification, is a rare neurodegenerative disorder characterized by the deposition of calcium salts in the basal ganglia, leading to a spectrum of neurological, cognitive, and psychiatric symptoms. This case report presents a 55-year-old female with a one-year history of progressive motor dysfunction, including tremors, dysarthria, and ataxia, along with cognitive decline and personality changes. Imaging studies revealed bilateral basal ganglia calcifications on both CT and MRI, confirming the diagnosis of Fahr's disease. The patient was started on symptomatic treatment with levodopa-carbidopa for motor symptoms and antidepressants for psychiatric disturbances. Despite some improvement in motor function, her cognitive decline continued to progress. The case emphasizes the importance of neuroimaging in diagnosing Fahr's disease and highlights the challenges of managing this rare disorder, particularly in its sporadic form. Treatment remains symptomatic, and a multidisciplinary approach is essential to address the diverse needs of patients. This case contributes to the understanding of Fahr's disease and underscores the need for further research into its pathophysiology and management.

Indexed as

antidepressantsbasal ganglia calcificationcognitive declinefahr diseaselevodopamovement disorderneurodegenerative disorderneuroimagingpsychiatric disturbancesrare diseases

Identifiers

PMID39996196
PMCPMC11849700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.