Evidence map›Paper›PMID 39996158›Full record

ArticleToxicology research2025

Acute anxiogenic effect of lisdexamphetamine dimesylate in zebrafish: implications of off-label cognitive enhancement use.

Nicole Berton, Luciane Dellazari da Silva do Prado, Jessica Nardi, Inara Carbonera Biazus, Laíse Mattiollo, Karen Julia de Souza Dos Santos, Nicoli da Rosa Amaral, Lisiane Siqueira, Amanda Carolina Cole Varela, Gabriéla Witkowski Rutikoski and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicole BertonPrograma de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, Rio Grande do Sul, 99052-900, Brazil.
Luciane Dellazari da Silva do PradoPrograma de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, Rio Grande do Sul, 99052-900, Brazil.
Jessica NardiPrograma de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, Rio Grande do Sul, 99052-900, Brazil.ORCID https://orcid.org/0000-0001-8793-6183
Inara Carbonera BiazusCurso de Farmácia, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, 99052-900, Rio Grande do Sul, Brazil.
Laíse MattiolloCurso de Farmácia, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, 99052-900, Rio Grande do Sul, Brazil.
Karen Julia de Souza Dos SantosCurso de Farmácia, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, 99052-900, Rio Grande do Sul, Brazil.
Nicoli da Rosa AmaralPrograma de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, Rio Grande do Sul, 99052-900, Brazil.
Lisiane SiqueiraPrograma de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Avenida Roraima, Bairro Camobi, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
Amanda Carolina Cole VarelaPrograma de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Avenida Roraima, Bairro Camobi, Santa Maria, 97105-900, Rio Grande do Sul, Brazil.
Gabriéla Witkowski RutikoskiCurso de Medicina Veterinária, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, 99052-900, Rio Grande do Sul, Brazil.
Leonardo José Gil BarcellosPrograma de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, Rio Grande do Sul, 99052-900, Brazil.
Luciana Grazziotin Rossato-GrandoPrograma de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, BR 285, São José, Passo Fundo, Rio Grande do Sul, 99052-900, Brazil.ORCID https://orcid.org/0000-0003-4574-855X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The off-label use of lisdexamphetamine dimesylate (LDX), a prodrug of dextroamphetamine, for cognitive enhancement has raised concerns due to its potential risk effects in neurotypical individuals. This study investigates the acute toxic effects of LDX exposure in zebrafish (

Indexed as

anxietycognitive enhancementneurobehavioral effectspsychostimulantssmart drugs

Identifiers

PMID39996158
PMCPMC11847156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.