ArticlePhotoacoustics2025
Collagen fibers quantification for liver fibrosis assessment using linear dichroism photoacoustic microscopy.
Article in Photoacoustics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Review
- [Dual-wavelength photoacoustic microscopy for evaluation of microcirculatory dysfunction and spatial heterogeneity in mice with liver fibrosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Deep learning-enabled high-performance multiphoton fluorescence vascular imaging using clinically approved fluorescent probes.iScience · 2026Article
- Label-free mid-infrared dichroism-sensitive photoacoustic microscopy for histostructural analysis of engineered heart tissues.Light, science & applications · 2026Article
- Article
- Sparse scanning encoding and neural network decoding for compressed photoacoustic microscopy.Photoacoustics · 2025Article
- Residual-conditioned sparse transformer for photoacoustic image artifact reduction.Photoacoustics · 2025Article
- High spectral energy density all-fiber nanosecond pulsed 1.7 μm light source for photoacoustic microscopy.Photoacoustics · 2025Article
- High resolution photoacoustic vascular image reconstruction through the fast residual dense generative adversarial network.Photoacoustics · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver fibrosis represents a progressive pathological condition that can culminate in severe hepatic dysfunction, potentially advancing to cirrhosis and liver cancer. The extent of liver fibrosis is intrinsically associated with the quantity of collagen fibers. Although liver biopsy and ultrasound imaging are standard diagnostic tools, their application is constrained by risks of significant complications and variability in different investigators, respectively. In this study, we utilized linear dichroism photoacoustic microscopy (LDPAM) to visualize and quantify collagen fibers, which exhibit specific absorption of polarized light, subsequently calculating a collagen fibers degree of dichroism (CDOD) score. We obtained high-resolution images of liver structures, with an emphasis on collagen fibers within the hepatic tissue. Using the CDOD score, we categorized liver fibrosis into three distinct stages: normal, early, and advanced. For validation purposes, collagen fibers were visualized with Sirius-red staining and quantitatively assessed through the collagen proportional area (CPA) score. Our results demonstrated a significant correlation between the CDOD and CPA scores, with a Pearson coefficient of 0.95. This approach presents a promising and non-invasive method for assessing liver fibrosis by quantifying collagen fibers.
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