Evidence map›Paper›PMID 39995994›Full record

ArticlePeerJ2025

Integrated multiomics analysis highlights the immunosuppressive role of granulin precursor positive macrophages in hepatocellular carcinoma.

Jun Li, Weizhen Huang, Junjie Kuang, Siwei Zhou, Yi Li, Yuan Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun Li *Shantou University Medical College, Shantou, China.
Weizhen Huang *The Second Department of Oncology, The First Huizhou Affiliated Hospital of Guangdong Medical University, Huizhou, China.
Junjie KuangThe Second Department of Oncology, The First Huizhou Affiliated Hospital of Guangdong Medical University, Huizhou, China.ORCID 0000-0001-8587-5065
Siwei ZhouThe Second Department of Oncology, The First Huizhou Affiliated Hospital of Guangdong Medical University, Huizhou, China.
Yi LiThe Second Department of Oncology, The First Huizhou Affiliated Hospital of Guangdong Medical University, Huizhou, China.
Yuan XiaThe Second Department of Oncology, The First Huizhou Affiliated Hospital of Guangdong Medical University, Huizhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been reported that tumor-associated macrophages (TAMs) play a complicated role in cancer occurrence and development, immune escape, and immune checkpoint blockade (ICB) resistance. However, the role of granulin precursor (GRN) highly expressed macrophages (hereafter refer to GRN

Indexed as

Carcinoma, HepatocellularGranulinsLiver NeoplasmsMacrophagesTumor-Associated MacrophagesCD8-Positive T-LymphocytesGene Expression Regulation, NeoplasticHumansMultiomicsPrognosisProgranulinsTumor MicroenvironmentGranulinsGRN protein, humanProgranulinsGranulin precursorImmune checkpoint blockadeT-cell exhaustionTumor-associated macrophagesTumor microenvironment

Identifiers

PMID39995994
PMCPMC11849516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.