Evidence map›Paper›PMID 39995975›Full record

ArticleMolecular therapy. Nucleic acids2025

TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis.

Jing Li, Yosuke Nagasaka, Hongtao Shen, Xinyu Zhou, Jianjie Ma, Dilza Trevisan-Silva, Nicholas E Sherman, Jayakrishna Ambati, Bradley D Gelfand, Lian-Wang Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing LiDivision of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Yosuke NagasakaDepartment of Ophthalmology, University of Virginia, Charlottesville, VA 22903, USA.
Hongtao ShenDivision of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Xinyu ZhouDivision of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Jianjie MaDivision of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Dilza Trevisan-SilvaSchool of Medicine Core Facilities, University of Virginia, Charlottesville, VA 22903, USA.
Nicholas E ShermanSchool of Medicine Core Facilities, University of Virginia, Charlottesville, VA 22903, USA.
Jayakrishna AmbatiDepartment of Ophthalmology, University of Virginia, Charlottesville, VA 22903, USA.
Bradley D GelfandDepartment of Ophthalmology, University of Virginia, Charlottesville, VA 22903, USA.
Lian-Wang GuoDivision of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-mesenchymal transition (EMT) is associated with retinal pigment epithelium (RPE) dysfunction in degenerative retinal diseases. However, the role of partial EMT (pEMT), a hybrid state exhibiting both epithelial and mesenchymal markers, remains poorly understood in this context. Our previous research demonstrated that TMEM97 ablation in mice worsens photoreceptor loss in an oxidant-induced RPE damage model. Here, we link TMEM97 to pEMT in RPE cells and explore the underlying molecular mechanisms. We found that re-expressing TMEM97 in the RPE of TMEM97-knockout mice, via subretinal lentiviral delivery, mitigated oxidant (NaIO

Indexed as

AMDcateninE-cadherinMT: Oligonucleotides: Therapies and ApplicationsN-cadherinpartial EMTphotoreceptorretinal degenerationRPEsigma-2 receptorZO-1

Identifiers

PMID39995975
PMCPMC11848774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.