Evidence map›Paper›PMID 39995960›Full record

ArticleTransplantation direct2025

Feasibility and Optimization of Donation Advisor: a Decision Support Tool for Deceased Organ Donation and Transplantation.

Sonny Dhanani, Rashi Ramchandani, Jill Allan, Natasha Hudek, Christophe L Herry, Nathan Scales, Neill K J Adhikari, Jamie C Brehaut, Karen E A Burns, Michaël Chassé and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sonny DhananiDivision of Critical Care, Department of Pediatrics, The Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0003-0780-8291
Rashi RamchandaniDepartment of Medicine, Faculty of Medicine University of Ottawa, Ottawa, ON, Canada.
Jill AllanClinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Natasha HudekClinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Christophe L HerryClinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Nathan ScalesClinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Neill K J AdhikariInterdepartmental Division of Critical Care Medicine and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.
Jamie C BrehautClinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Karen E A BurnsLi Ka Shing Knowledge Institute, Toronto, ON, Canada.
Michaël ChasséDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
Akshai M IyengarDepartment of Critical Care Medicine, Queensway Carleton Hospital, Ottawa, ON, Canada.
Maureen O MeadeDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Tim RamsayClinical Epidemiology Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Damon C ScalesInterdepartmental Division of Critical Care Medicine and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.
Markus SelznerDepartment of Surgery, University Health Network, Toronto, ON, Canada.
Alp SenerDepartment of Surgery & Microbiology and Immunology, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Marat SlessarevDepartment of Medicine, Western University, London, ON, Canada.
Heather TalbotCanadian Donation and Transplant Research Program, Toronto, ON, Canada.
Matthew J WeissPopulation Health and Optimal Health Practices Research Unit, Trauma-Emergency-Critical Care Medicine, Université Laval, Quebec City, QC, Canada.
Jeffrey ZaltzmanSt. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, ON, Canada.
Andrew J E SeelyDepartment of Medicine, Faculty of Medicine University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to evaluate the ability of Donation Advisor (DA), a validated clinical decision support tool that uses continuous monitoring, variability analysis, and predictive models, to (i) predict likelihood of successful donation after circulatory determination of death (DCD) before withdrawal of life-sustaining measures (WLSM), and (ii) describe ischemia during WLSM in DCD patients. Methods: Eligible patients were screened at the 5 sites where DA was implemented. DA reports were generated in real time but shown to clinicians after the donation was complete (noninterventional). Clinicians were interviewed for improvement of the tool. Results: We enrolled 34 donor patients in the study; 27 had DCD attempts and 20 proceeded to organ recovery. DA reports were generated before WLSM in all 27 attempted DCD patients (100%) while post-WLSM ischemia reports were generated in 26 of 27 DCD attempts (96%). Nineteen of 34 involved clinicians completed interviews, 10 from intensive care, and 9 from transplantation team members. Following a user-centered design approach, feedback was used to create 5 versions. Revisions included additions, removals, clarifications, and formatting changes; the number of revisions decreased with each amendment. The report's predictive scores were found to be useful by most practitioners (83%). We identified barriers and drivers to use the report in future practice, some of which may be addressed through improved education and awareness. Conclusions: DA can be deployed in real time during the DCD process. The usefulness and usability of the DA report has improved through user feedback; both barriers and drivers to implementation exist.

Identifiers

PMID39995960
PMCPMC11850036

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.