ArticleHeliyon2025
Reference intervals for thyroid-stimulating hormone in the adult Lebanese population: Results from the last decade.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Reference Values for Biochemical Analytes in An Iranian Population: The Tehran Lipid and Glucose Study.International journal of endocrinology and metabolism · 2026Review
- Establishment of Reference Intervals for Plasma TSH Across the Lifespan in an Algerian Mediterranean Population.Journal of clinical laboratory analysis · 2026Article
- Comparison of thyroid hormones reference intervals based on thyroid antibody levels: A multicenter study.PloS one · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Thyroid Stimulating Hormone (TSH) is the most accurate marker in the assessment of thyroid function. Establishing a reference interval (RI) for TSH is essential for interpreting results of thyroid function tests. TSH RI in the Lebanese population using the indirect method is lacking. The aim of this study is to establish TSH RI according to age and gender, and to assess its trend over the last decade using the indirect method. Methods: TSH values of 80156 outpatient subjects (age range 18-99) were retrospectively collected between January 2011 and April 2021 from a tertiary university medical center in Beirut. TSH was measured using the same chemiluminescent assay (Immulite 2000). Results: The median TSH was 1.4 mIU/L (IQ 0.94-2.10). TSH RI was wider compared to the manufacturer one (0.31-4.95 mIU/L vs 0.40-4.0, p < 0.001). There was a decrease in lower reference limit (LRL) and an increase in upper reference limit (URL) with the increase in age categories (p < 0.001 for both comparisons). RI was broader in women compared to men (respectively 0.29-5.20 vs 0.35-4.48 mIU/L, p < 0.001). There are significant differences in the median, LRL and URL across the years and in all age categories (p < 0.001). TSH RI using the indirect method was wider than the direct method one (p < 0.001). Conclusion: Using the indirect method, TSH RI in the Lebanese population is wider than the manufacturers'one and that those obtained by the direct method and varies according to age, gender and over time. A periodic reevaluation of RI for each population should be done.
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