Evidence map›Paper›PMID 39995873›Full record

ArticleiScience2025

Imaging lipid rafts reveals the principle of ApoE4-induced Aβ upregulation in human neurons.

Se-In Lee, Heejin Lim, Na Yeon Kim, Jichang Yu, Joonho Cho, Hyein Lee, Dae Won Moon, Jinsoo Seo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Se-In LeeDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.
Heejin LimDepartment of New Biology, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.
Na Yeon KimDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.
Jichang YuDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.
Joonho ChoDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.
Hyein LeeDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.
Dae Won MoonDepartment of New Biology, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.
Jinsoo SeoDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology, Daegu 42988 South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid rafts in plasma membranes are thought to provide a platform for regulating signaling pathways by increasing the expression or proximity of proteins in the same pathway. Despite this understanding, the absence of direct, simultaneous observations of lipid rafts and their affiliated proteins has hindered a comprehensive assessment of their roles across various biological contexts. Amyloid-β (Aβ), a hallmark of Alzheimer's disease (AD), is generated from the sequential cleavage of amyloid precursor proteins (APPs) by β- and

Indexed as

Biological sciencesCellular neuroscienceNatural sciencesNeuroscienceTechniques in neuroscience

Identifiers

PMID39995873
PMCPMC11848483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.