Evidence map›Paper›PMID 39995862›Full record

ArticleiScience2025

Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress

Juan A Garcia-Sanchez, Estelle Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre and 5 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Juan A Garcia-SanchezUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Estelle BonnetUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Céline LoubatierUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Anne DoyeUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Guillaume PaillierUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Fabien SeguiUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Frédéric LarbretUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Paul ChaintreuilUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Ludovic BatisticUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Cédric TorreUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Marcel DeckertUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Jolanta PolanowskaUniversité de Montpellier, CNRS, CRBM, Montpellier, France.
Patrick MunroUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Laurent BoyerUniversité Côte d'Azur, INSERM, C3M, Nice, France.
Orane VisvikisUniversité Côte d'Azur, INSERM, C3M, Nice, France.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Transcription factor EB (TFEB) is a key transcription factor that orchestrates the cellular response to stress. Dysregulation of TFEB is associated with a range of human diseases, and understanding the regulatory mechanisms of TFEB is crucial for identifying potential drug targets. In this study, we used

Indexed as

Cell biologyFunctional aspects of cell biology

Identifiers

PMID39995862
PMCPMC11848471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.