Evidence map›Paper›PMID 39995841›Full record

ArticleFrontiers in oncology2025

A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review.

Zhihua Li, Jian Chu, Wennan Shen, Junnan Chen, Yuemei Dong, Manze Zhang, Nan Zhao, Wei Zhao, Haoran Zha, Ning Wang and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhihua Li *Department of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Jian Chu *Department of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Wennan Shen *Department of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Junnan ChenDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Yuemei DongDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Manze ZhangDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Nan ZhaoDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Wei ZhaoDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Haoran ZhaDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Ning WangDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Yalin HanDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.
Zhaoxia LiDepartment of Oncology, Chinese People's Liberation Army Rocket Force Characteristic Medical Center, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. The treatment was prescribed based on the detection of a BRAF non-V600E mutation in the cerebrospinal fluid (CSF). We reviewed the literature and evaluated survival benefits in patients with LM harboring BRAF non-V600E mutations treated with CSF chemotherapy and mitogen-activated extracellular signal-regulated kinase inhibitors.

Indexed as

BRAF non-V600E mutationcase reportleptomeningeal metastasisNSCLCtrametinibvision loss

Identifiers

PMID39995841
PMCPMC11847661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.