ArticleFrontiers in medicine2024
Diagnostic efficacy and necessity of 18F-FDG PET/CT in fever of unknown origin: insights from a retrospective cohort study.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Unsupervised clustering of PET/CT features in fever of unknown origin (FUO) and inflammation of unknown origin (IUO).Frontiers in medicine · 2026Article
- Precision Management of Tumor-Associated Fever: From Classification to Targeted Intervention.Cancer management and research · 2026Review
- Machine learning approach to determine the diagnostic value and predictive factors of PET/CT in FUO and IUO patients.Frontiers in medicine · 2026Article
- Role ofJournal of clinical medicine · 2025Review
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5 authors.
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Abstract
Background: Despite advancements in medical examination equipment and techniques, fever of unknown origin (FUO) remains challenging in internal medicine. Purpose: This study evaluates the diagnostic efficacy and necessity of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with FUO. Methods: We retrospectively analyzed the results of 18F-FDG PET/CT in a cohort of 284 patients with FUO admitted to the Department of Infection at the First Hospital of Jilin University between January 2018 and March 2024. All patients received a final clinical diagnosis after various treatments, which helped determine the diagnostic relevance of identified lesions using 18F-FDG PET/CT. Additionally, univariate and multivariate logistic regression analyses were performed to evaluate the predictive value of relevant laboratory indices on the true-positive results of 18F-FDG PET/CT. The diagnostic performance for different etiologies of FUO was assessed by calculating the area under the receiver operating characteristic curve. Results: Of the 284 enrolled patients, infectious diseases were diagnosed in 53 (18.7%), non-infectious inflammatory diseases in 76 (26.8%), malignant tumors in 66 (23.2%), and 89 (31.3%) remained undiagnosed. The final diagnoses of 136 patients (47.9%) correlated with their 18F-FDG PET/CT results, yielding a sensitivity of 79.5%, specificity of 61.1%, positive predictive value of 75.6%, and negative predictive value of 66.3%. Furthermore, a correlation was found between localized pain, prolonged activated partial thromboplastin time, and true-positive 18F-FDG PET/CT results. Conclusion: The high diagnostic efficacy of 18F-FDG PET/CT in FUO suggests its potential as a routine imaging modality, which could enhance patient management and reduce the need for costly and unnecessary invasive procedures. The identification of clinical factors that are predictive of true-positive diagnosis could facilitate more effective allocation of PET/CT imaging.
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