Evidence map›Paper›PMID 39995753›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Transcription factor RUNX1 regulates coagulation factor XIII-A (

Fabiola Del Carpio-Cano, Natthapol Songdej, Liying Guan, Guangfen Mao, Lawrence E Goldfinger, Jeremy G T Wurtzel, Kiwon Lee, Michele P Lambert, Mortimer Poncz, A Koneti Rao

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Fabiola Del Carpio-CanoSol Sherry Thrombosis Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Natthapol SongdejSol Sherry Thrombosis Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Liying GuanSol Sherry Thrombosis Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Guangfen MaoSol Sherry Thrombosis Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Lawrence E GoldfingerCardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Jeremy G T WurtzelCardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Kiwon LeeDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Michele P LambertDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Mortimer PonczDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
A Koneti RaoSol Sherry Thrombosis Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

Funding

New Mechanistic Insights & Therapeutic Applications of Megakaryocytes/PlateletsR35HL150698 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Mortimer Poncz · 2020 to 2026
$7.3M
Human Platelet Defects in Transcription Factor RUNX1 HaplodeficiencyR01HL109568 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2013 to 2022
$3.4M
Novel small G protein pathway regulators of GPVI signaling in plateletsR01HL137207 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GOLDFINGER, LAWRENCE E, KUNAPULI, SATYA P. · 2017 to 2020
$2.5M
Runx1 Haplodeficiency, Endocytosis and Vesicle transportR01HL137376 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2018 to 2021
$1.8M
Function and regulation of constitutive protein translation in plateletsR01HL159006 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI GOLDFINGER, LAWRENCE E · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL109568NHLBI NIH HHS R01 HL137207NHLBI NIH HHS R01 HL137376NHLBI NIH HHS R01 HL159006NHLBI NIH HHS R35 HL150698
6 · The paper itself

Abstract

Background: Germline Objectives: To understand RUNX1 regulation of Methods: We performed studies in platelets, human erythroleukemia (HEL) cells, and human CD34+ cell-derived megakaryocytes including on clot contraction in cells following small inhibitor RNA knockdown (KD) of RUNX1 or F13A1. Results: Platelet Conclusion: RUNX1 regulates platelet-megakaryocyte

Indexed as

clotF13A1FXIIImegakaryocytesplateletsRUNX1

Identifiers

PMID39995753
PMCPMC11849627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.