ArticleQuantitative imaging in medicine and surgery2025
Evaluation of glymphatic system dysfunction in patients with insomnia via diffusion tensor image analysis along the perivascular space.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glymphatic dysfunction across sleep disorders: a meta-analysis of DTI-ALPS studies.Frontiers in neurologyPooled it
- Harnessing Brain Age-Specific Effects on the Associations Between Sleep Quality, Glymphatic Function, and Cognition in Normal Ageing Adults: Insights for Gerotherapeutics.Neurology and therapy · 2026Article
- Imaging study of white matter microstructural damage and glymphatic system dysfunction in patients with primary insomnia: a combined analysis based on PSMD, DTI-ALPS, and EPVS.Quantitative imaging in medicine and surgery · 2026Article
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.Psychological medicine · 2026Article
- Vascular permeability mediates contralateral glymphatic dysfunction across glioma grades and IDH status.Neuroradiology · 2026Article
- Major neurocognitive impairment among Elders in Southwest Ethiopia community based cross sectional study.Discover mental health · 2026Article
- Sleep-Dependent Clearance of Brain Metabolites via the Glymphatic System: Implications for Alzheimer's Pathophysiology.Brain and behavior · 2026Review
- Role of glymphatic system function in cognitive dysfunction among patients with bipolar disorder.The international journal of neuropsychopharmacology · 2026Article
- Neuroprotective effects of rTMS in chronic insomnia: is glymphatic system modulation the key player?Sleep · 2025Article
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Authors and funding
9 authors.
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Abstract
Background: The glymphatic system is a crucial pathway for the clearance of metabolic waste from the brain, and its dysfunction has been linked to various neurodegenerative disorders. This study examined the connection between insomnia and glymphatic system dysfunction, offering a novel perspective on the pathophysiological mechanisms underlying insomnia. Methods: We prospectively recruited 25 patients with insomnia and 37 healthy controls for a case-control study. All participants underwent routine magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) scans. Glymphatic activity was measured via diffusion tensor image analysis along the perivascular space (DTI-ALPS). All patients with insomnia underwent a polysomnogram (PSG) examination and were evaluated using the Pittsburgh Sleep Quality Index (PSQI). We used United Imaging Healthcare artificial intelligence to count the number of enlarged perivascular spaces (ePVSs) in the centrum semiovale, corona radiata, basal ganglia, and hippocampal regions. Results: The left ALPS index, right ALPS index, and average ALPS index were found to be lower in the insomnia group than in the control group [P false discovery rate (P Conclusions: Insomnia is associated with impairments in glymphatic circulation, and the average ALPS index can serve as an imaging biomarker for glymphatic dysfunction in insomnia, aiding in the prevention of further progression to dementia.
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