ArticleReports of biochemistry & molecular biology2024
Hydroalcoholic Sumac Extract as a Protective Agent Against X-Ray-Induced Pulmonary Fibrosis.
Article in Reports of biochemistry & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Rosmarinic Acid Attenuates Paraquat-Induced Lung Injury by Suppressing Inflammatory Responses in Mice.Reports of biochemistry & molecular biology · 2025Article
- New Exploration of Therapeutic Targets for Radiation Pneumonitis: Comparative Analysis of Molecular Pathways in Radiation-Induced and LPS-Induced Pneumonitis.International journal of medical sciences · 2025Review
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Authors and funding
5 authors.
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Abstract
Background: X-ray exposure can result in acute or chronic damage to lung tissue, leading to pneumonitis and fibrosis. Given the potent antioxidant properties of sumac, this study investigates the impact of hydroalcoholic sumac extract on X-ray-induced pulmonary fibrosis in rats. Methods: In this experimental study, 36 rats were randomly divided into six groups of six rats each. The treatment and sham groups received intraperitoneal administration of the extract daily for one week before exposure to X-ray radiation. On the seventh day, all rats except those in group 3 were exposed to 2 Gy of 6 MV X-rays using an electro-linear accelerator. Lung tissue was subsequently removed to assess the subacute effects of the extract. Data analysis involved independent sample t-tests and one-way ANOVA using SPSS 26. Results: A single dose of X-rays significantly increased oxidative stress and lung tissue damage in rats. However, rats receiving vitamin C and hydroalcoholic sumac extract at two different doses (100 and 400 mg/kg intraperitoneally) positively improved lung damage and decreased antioxidant parameters. Conclusions: The findings demonstrate that hydroalcoholic sumac extract can mitigate oxidative stress and enhance lung repair following X-ray radiation exposure.
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