ArticleReports of biochemistry & molecular biology2024
Correlation of Klotho Protein with Troponin-I as a Marker of Myocardial Damage in Iraqi Beta-Thalassemia Major Patients.
Article in Reports of biochemistry & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Beta thalassemia is a hereditary blood condition characterized by a decrease or absence in the production of the beta-globin chain of hemoglobin. Patients with beta-thalassemia major often require regular blood transfusions and are at an increased risk of developing complications such as iron overload and cardiac injury. In recent years, there has been increasing interest in Klotho protein as a multifunctional protein known for its anti-aging and cardio-protective properties. Several studies have revealed a potential correlation between Troponin, a protein released into the circulation as a result of heart muscle damage, and the level of Klotho protein. Methods: This study included thirty Beta-Thalassemia Major (β-TM) patients and thirty control healthy subjects. Levels of Klotho protein and Troponin-I were determined using the ELISA technique and measured for all participants. Results: Serum Klotho protein and Troponin-I levels were significantly elevated in β-TM patients compared to healthy control subjects (P< 0.001). A positive correlation was found between serum Klotho protein and Troponin-I in the β-TM patients' group. Conclusions: A positive correlation was found between serum Klotho protein and Troponin-I in the β-TM patients, which may highlight a relationship between Klotho and cardiac damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.