Evidence map›Paper›PMID 39995587›Full record

ArticleOsteoarthritis and cartilage open2025

Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study.

Khara A James, Tuhina Neogi, David T Felson, Patrick Corrigan, Cara L Lewis, Irene S Davis, Kathryn L Bacon, James C Torner, Cora E Lewis, Michael C Nevitt and 1 more

Abstract read
In one paragraph

Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khara A JamesNortheastern University, Boston, MA, USA.
Tuhina NeogiBoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USA.
David T FelsonBoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USA.
Patrick CorriganCleveland Clinic, Cleveland, OH, USA.
Cara L LewisBoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USA.
Irene S DavisMorsani College of Medicine, University of South Florida, Tampa, FL, USA.
Kathryn L BaconBoston University Chobanian & Avedisian School of Medicine, Section of Rheumatology, Boston, MA, USA.
James C TornerUniversity of Iowa, Iowa City, IO, USA.
Cora E LewisUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Michael C NevittUniversity of California, San Francisco, CA, USA.
Joshua J StefanikNortheastern University, Boston, MA, USA.

Funding

Project 3: Intraarticular MineralizationU19AG076471 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DAVID Tobin FELSON · 2023 to 2026
$49.0M
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
PRROPS: Pathways of Risk and Resilience for Overlapping Pain and SensitizationR01NS121419 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Emelia J. Benjamin, ROBERT R EDWARDS · 2021 to 2026
$3.7M
CAPSITE: Community Assessment of Pain and Sensitization in the ElderlyR01AG066010 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2025
$3.3M
Pain in community-based older African American Adults: The Jackson Heart StudyR01AG066914 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2024
$3.2M
NIAMS NIH HHS P30 AR072571NIA NIH HHS R01 AG066010NIA NIH HHS R01 AG066914NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIA NIH HHS U19 AG076471NINDS NIH HHS R01 NS121419
6 · The paper itself

Abstract

Objective: Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA. Design: Participants from the Multicenter Osteoarthritis study were included.Cadence was measured using a GAITRite walkway. Incident and worsening knee symptoms, pain with walking, and functional limitations were assessed at baseline and 2 years later. The association of cadence to each outcome was analyzed using log binomial regression. Cadence was assessed continuously as a 10-unit change and categorically using quartiles. Analyses were adjusted for age, sex, race, BMI, presence of tibiofemoral OA, depression, and history of knee injury. Sensitivity analyses were conducted for all outcomes adjusted for gait speed and stratified by sex. Results: Among 1600 participants (60.3 ​% female, age 67.1 ​± ​7.7 years), lower cadence was not significantly associated with incident or worsening knee symptoms, pain with walking, or functional limitations. For every 10-step/min decrease in cadence, the risk of incident knee symptoms increased by 10 ​% (RR ​= ​1.10, 95%CI [0.97, 1.25]), though this was not statistically significant and was attenuated after adjusting for gait speed (RR ​= ​0.95, 95%CI [0.80, 1.12]). No significant associations were observed for incident or worsening pain with walking or functional limitations. Sex-stratified analyses revealed inconsistent findings, including an increased risk for incident functional limitations in females (RR ​= ​1.45, 95%CI [1.02, 2.08]), which was attenuated after adjusting for gait speed. Conclusion: Lower cadence was not significantly associated with pain and function, suggesting that the interplay between cadence, gait speed, and clinical outcomes warrants further investigation.

Indexed as

CadenceGaitPainPhysical function

Identifiers

PMID39995587
PMCPMC11849617

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.