Evidence map›Paper›PMID 39995527›Full record

ReviewIndian journal of surgical oncology2024

Understanding Biologically Guided Radiotherapy: Essential Insights for Surgical Oncologists.

Gautam Sarma, Partha Pratim Medhi, Hrishikesh Kashyap, Shashi Bhushan Sharma, Rupam Kalita, Dhanjit Lahkar

Abstract readReview
In one paragraph

Review in Indian journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gautam SarmaDepartment of Radiation Oncology, All India Institute of Medical Sciences Guwahati, Changsari, Assam-781101 India.
Partha Pratim MedhiDepartment of Radiation Oncology, All India Institute of Medical Sciences Guwahati, Changsari, Assam-781101 India.
Hrishikesh KashyapDepartment of Radiation Oncology, All India Institute of Medical Sciences Guwahati, Changsari, Assam-781101 India.
Shashi Bhushan SharmaDepartment of Radiation Oncology, All India Institute of Medical Sciences Guwahati, Changsari, Assam-781101 India.
Rupam KalitaDepartment of Radiation Oncology, All India Institute of Medical Sciences Guwahati, Changsari, Assam-781101 India.
Dhanjit LahkarDepartment of Radiation Oncology, All India Institute of Medical Sciences Guwahati, Changsari, Assam-781101 India.ORCID 0009-0004-4242-0828

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The technology in the radiotherapy field is approaching a new evolution day by day. The image-guided radiotherapy (IGRT) approach has changed the radiotherapy treatment workflow scenario. The image acquired before radiotherapy treatment helps minimize uncertainty in target positioning for accurate radiation delivery. Biologically guided radiotherapy (BgRT) is a new approach in radiotherapy through the IGRT modality to track the target with the help of radiopharmaceuticals. It acquires the image through PET-CT and attaches it to a linear accelerator before treatment to verify the target volume. BgRT, a pioneering technology, stands out with its unique ability to adapt dose delivery based on biological features, which sets it apart from conventional IGRT. By utilizing PET detection, BgRT can rapidly adjust the position of the linear accelerator to accommodate target motion, enabling precise dose delivery while sparing surrounding normal tissues. This represents a significant advancement, allowing for real-time tracking and adjusting radiation doses according to biological changes within the tumor. Additionally, a single tracer injection and a single treatment plan can effectively target multiple metastatic lesions, streamlining the treatment process. However, due to radioactive tracer uptake, BgRT is more suitable for hypo-fractionated or stereotactic treatments than conventional fractionation. This article provides an overview of the technological advancements of BgRT and their clinical implications in modern radiation oncology.

Indexed as

Biologically guided radiotherapyIGRTPETRefleXion X1

Identifiers

PMID39995527
PMCPMC11846787

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.