Evidence map›Paper›PMID 39995289›Full record

ArticlePsychological medicine2025

Mapping connections between complex post-traumatic stress disorder and psychotic-like experiences among adolescents: a Gaussian and Bayesian network study.

Tommaso B Jannini, Valentina Socci, Adriano Schimmenti, Grazia Terrone, Lucia Sideli, Luis Alameda, Monica Aas, Giorgio Di Lorenzo, Cinzia Niolu, Rodolfo Rossi

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In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tommaso B JanniniDepartment of Experimental Medicine, Tor Vergata University of Rome, Rome, Italy.ORCID 0000-0003-2936-4150
Valentina SocciDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-4797-6911
Adriano SchimmentiDepartment of Human & Social Sciences, Kore University of Enna.ORCID 0000-0001-5181-2648
Grazia TerroneDepartment of History, Humanities and Society, Tor Vergata University of Rome, Rome, Italy.ORCID 0000-0002-7267-2629
Lucia SideliDepartment of Human Science, LUMSA University, Rome, Italy.ORCID 0000-0001-6124-6897
Luis AlamedaDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, National Psychosis Unit, South London and Maudsley NHS Foundation Trust, London, United Kingdom.ORCID 0000-0002-8621-2885
Monica AasSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.ORCID 0000-0002-2338-5826
Giorgio Di LorenzoDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.ORCID 0000-0002-0576-4064
Cinzia NioluDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.ORCID 0000-0001-6173-2684
Rodolfo RossiDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.ORCID 0000-0002-6857-898X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplex post-traumatic stress disorder (cPTSD) is a newly recognized condition characterized by core PTSD symptoms and disturbances in self-organization (DSO) that has been associated with psychotic-like experiences (PLEs). This study employs two psychopathology network approaches to identify which post-traumatic symptoms are related to PLEs in a sample of late adolescents. We propose that cPTSD symptoms play a crucial role in explaining the co-occurrence of trauma and PLEs.

methodsA sample of 1010 late adolescents provided measures of post-traumatic symptomatology and PLEs. We estimated the Gaussian graphical network structure of PTSD/cPTSD symptoms and PLEs and assessed their bridge centrality indices. Bayesian network analysis was then used to estimate a directed acyclic graph (DAG). Gender was set as a moderator in both Gaussian and Bayesian models.

resultsResults show that affect dysregulation, a cPTSD domain, presented the highest bridge connection with the PLE cluster. Bayesian network analysis identified a pathway going from cPTSD items of worthlessness and relational dysregulation, to PLE items of paranoia and social anxiety. Additionally, we found relevant gender differences in network connectivity, with females showing higher connectivity compared to males.

conclusionsOur findings highlight the central role of affect dysregulation and negative self-concept in linking cPTSD to PLE symptoms, with specific differences according to gender. These insights underscore the need for targeted, gender-sensitive approaches in the prevention and treatment of PLEs among adolescents, emphasizing early intervention and tailored treatment strategies.

Indexed as

Psychotic DisordersStress Disorders, Post-TraumaticAdolescentBayes TheoremFemaleHumansMaleNormal DistributionSex FactorsBayesian network analysiscPTSDgenderpsychosispsychotic-like experiencestrauma

Identifiers

PMID39995289
PMCPMC12080637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.